Product Number |
ARP64454_P050 |
Product Page |
www.avivasysbio.com/flnc-antibody-n-terminal-region-arp64454-p050.html |
Name |
FLNC Antibody - N-terminal region (ARP64454_P050) |
Protein Size (# AA) |
2692 amino acids |
Molecular Weight |
296kDa |
NCBI Gene Id |
2318 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Filamin C, gamma |
Alias Symbols |
ABPA, ABPL, FLN2, MFM5, MPD4, RCM5, CMH26, ABP-280, ABP280A |
Peptide Sequence |
Synthetic peptide located within the following region: VGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEP |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. |
Protein Interactions |
RAPGEF2; TRIM63; TRIM55; XIRP1; XIRP2; SYNPO2; UBC; KCMF1; CTTNBP2NL; ANKRD28; ARFGEF2; NCAPD2; TXNL1; PSMD13; PSMD12; PSMD3; NUP88; IKBKB; FLNB; AP3S1; NPM1; IGSF8; FN1; IQCB1; TP63; VCAM1; RPS6KA2; DYNLRB1; NUP133; SAP30BP; SF3A3; SRSF9; ENO1; EEF1G; EE |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-FLNC (ARP64454_P050) antibody |
Blocking Peptide |
For anti-FLNC (ARP64454_P050) antibody is Catalog # AAP64454 |
Immunogen |
The immunogen is a synthetic peptide directed towards the N-terminal region of Human FLNC |
Uniprot ID |
Q14315 |
Protein Name |
Filamin-C |
Publications |
FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy. JACC Basic Transl Sci. 1, 344-359 (2016). 28008423 |
Protein Accession # |
NP_001120959 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_001127487 |
Tested Species Reactivity |
Human |
Gene Symbol |
FLNC |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
Image 1 | Human HepG2
| WB Suggested Anti-FLNC Antibody Titration: 1.0 ug/ml Positive Control: HepG2 Whole Cell |
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Image 2 |
| Surface Plasmon Resonance Kinetic Characterization of Polyclonal Antibody Affinity. Purified polyclonal antibodies were immobilized on a Protein A/G coated Carterra LSA sensor chip (PAGH200M) at concentrations of 5, and 50 ug/mL in duplicate. Antibodies on the surface were exposed to interaction with peptides sequentially via microfluidic controlled flow at 333nM peptide concentration for kinetic characterization of the binders for affinity and specificity, followed by curve fitting using the Kinetics software. Kd determinations for both concentrations were averaged and results and standard deviation are shown.
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