MTNR1B Antibody - N-terminal region (ARP64072_P050)

• Product Number: ARP64072_P050
• Name: MTNR1B Antibody - N-terminal region (ARP64072_P050)
• Protein Size (# AA): 362 amino acids
• Molecular Weight: 40 kDa
• NCBI Gene Id: 4544
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Melatonin receptor 1B
• Description:
  View product citations for MTNR1B Antibody - N-terminal region (ARP64072_P050) on CiteAb
• Alias Symbols: MT2, FGQTL2, MEL-1B-R
• Peptide Sequence: Synthetic peptide located within the following region: SFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDV
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Description of Target: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.
• Protein Interactions: GNAI1; GPR50; ITM2C; HNRNPA0; GNB4; PPM1G; PI4KA; PDIA6; VPS35; IRS4; COPA; CTNND1; MTNR1B; MTNR1A; FLNA; YWHAQ; GNB1; GNAI3; GNAI2; HSPA5; CANX;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Blocking Peptide: For anti-MTNR1B (ARP64072_P050) antibody is Catalog # AAP64072
• Uniprot ID: P49286
• Protein Name: Melatonin receptor type 1B
• Publications:

  Melatonin enhances porcine embryo development via the Nrf2/ARE signaling pathway. J Mol Endocrinol. 63, 175-185 (2019). 31408847

  Melatonin-Nrf2 Signaling Activates Peroxisomal Activities in Porcine Cumulus Cell-Oocyte Complexes. Antioxidants (Basel). 9, (2020). 33153240

  Santoro, R. et al. Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation. Carcinogenesis 34, 1051-61 (2013). 23354312

  Stimulatory Effects of Melatonin on Porcine In Vitro Maturation Are Mediated by MT2 Receptor. Int J Mol Sci. 19, (2018). 29861447

• Protein Accession #: NP_005950
• Purification: Affinity Purified
• Nucleotide Accession #: NM_005959
• Tested Species Reactivity: Human
• Gene Symbol: MTNR1B
• Predicted Species Reactivity: Human, Pig, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Human: 100%; Pig: 79%; Rabbit: 79%
• Image 1: Human HepG2
  
  WB Suggested Anti-MTNR1B Antibody
  Titration: 1.0 ug/ml
  Positive Control: HepG2 Whole Cell