| Product Number |
ARP63498_P050 |
| Product Page |
www.avivasysbio.com/wasl-antibody-middle-region-arp63498-p050.html |
| Name |
WASL Antibody - middle region (ARP63498_P050) |
| Protein Size (# AA) |
505 amino acids |
| Molecular Weight |
56kDa |
| NCBI Gene Id |
8976 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Wiskott-Aldrich syndrome-like |
| Alias Symbols |
NWASP, WASPB, N-WASP |
| Peptide Sequence |
Synthetic peptide located within the following region: ISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. |
| Protein Interactions |
RHOJ; ARPC3; RNF8; NCK2; WIPF1; SDCBP; PTK6; GRB2; IQGAP1; WWOX; SNX9; APBB1; PRPF40A; FNBP1L; FNBP1; TRIP10; PSTPIP1; ACTG1; SORBS3; ACTR2; ACTR3; LCK; CDC42; RPL7AP66; ZNF395; BAIAP2; ARPC1B; FCHSD2; IPO5; HP; HSP90AB1; HSP90AA1; SRC; WASF2; APP; WIPF2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-WASL (ARP63498_P050) antibody |
| Blocking Peptide |
For anti-WASL (ARP63498_P050) antibody is Catalog # AAP63498 |
| Uniprot ID |
O00401 |
| Protein Name |
Neural Wiskott-Aldrich syndrome protein |
| Protein Accession # |
NP_003932 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003941 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
WASL |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit |
| Application |
WB, IHC |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Fetal Lung
 | WB Suggested Anti-WASL Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Lung |
|
| Image 2 | Mouse Skeletal Muscle
 | Host: Mouse
Target Name: WASL
Sample Tissue: Mouse Skeletal Muscle
Antibody Dilution: 1ug/ml |
|
| Image 3 | Human heart
 | Rabbit Anti-WASL Antibody
Catalog Number: ARP63498_P050
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Cytoplasmic
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec |
|
