| Product Number |
ARP63180_P050 |
| Product Page |
www.avivasysbio.com/nf2-antibody-c-terminal-region-arp63180-p050.html |
| Name |
NF2 Antibody - C-terminal region (ARP63180_P050) |
| Protein Size (# AA) |
507 amino acids |
| Molecular Weight |
56kDa |
| NCBI Gene Id |
4771 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Neurofibromin 2 (merlin) |
| Alias Symbols |
ACN, SCH, BANF, merlin-1 |
| Peptide Sequence |
Synthetic peptide located within the following region: MAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPA |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. |
| Protein Interactions |
VPRBP; CD44; UBC; KDM1A; AMOTL2; YAP1; PPP1R8; UBD; CCNB1IP1; HGS; CUL4A; DDB1; GPS1; WWC1; PYGO2; AMOT; SCHIP1; SGSM3; NF2; TSC1; TARBP2; SLC9A3R1; PAK1; XPO1; PXN; SDCBP; RALGDS; SPTBN1; ERBB2; ITGB1; EZR; CTNNB1; AGAP2; AKT1; RIT1; ARHGAP32; SOS1; MED2 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-NF2 (ARP63180_P050) antibody |
| Blocking Peptide |
For anti-NF2 (ARP63180_P050) antibody is Catalog # AAP63180 |
| Uniprot ID |
P35240-4 |
| Protein Name |
Merlin |
| Publications |
Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons. Cell. Mol. Neurobiol. , (2017). 28236056 |
| Protein Accession # |
NP_861968 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_181830 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
NF2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human Fetal Kidney
 | Host: Rabbit
Target Name: NF2
Sample Type: Human Fetal Kidney
Antibody Dilution: 1.0ug/ml |
| | Image 2 | Human 293T
 | Host: Rabbit
Target Name: NF2
Sample Type: Human 293T
Antibody Dilution: 1.0ug/ml |
| | Image 3 | Human Fetal Brain
 | WB Suggested Anti-NF2 Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Brain |
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