CTPS2 Antibody - N-terminal region (ARP62443_P050)

• Product Number: ARP62443_P050
• Name: CTPS2 Antibody - N-terminal region (ARP62443_P050)
• Protein Size (# AA): 586 amino acids
• Molecular Weight: 64kDa
• NCBI Gene Id: 56474
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: CTP synthase II
• Alias Symbols: DKFZp686C17207, FLJ43358, MGC32997
• Peptide Sequence: Synthetic peptide located within the following region: AKRENFCNIHVSLVPQLSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSS
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Description of Target: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
• Protein Interactions: CTPS2; SPG21; RNF2; LRSAM1; EHD4; EHD1; PLIN3; MTMR2; WARS; PRKDC; NUCB1; METTL1; KTN1; HSF1; GTF2I; DHPS; RPL37A; RPL23A; FGFR1; CTBP2; UBC; SUMO2; OTUD5;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-CTPS2 (ARP62443_P050) antibody is Catalog # AAP62443 (Previous Catalog # AAPP48741)
• Uniprot ID: Q9NRF8
• Protein Name: CTP synthase 2
• Sample Type Confirmation:

  CTPS2 is supported by BioGPS gene expression data to be expressed in HeLa

• Protein Accession #: NP_787055
• Purification: Affinity Purified
• Nucleotide Accession #: NM_175859
• Tested Species Reactivity: Human
• Gene Symbol: CTPS2
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Image 1: Human Hep-2
  
  Sample Type:
  Human Hep-2 cells
  Primary Antibody Dilution:
  1:500
  Secondary Antibody:
  Goat anti-rabbit-Alexa Fluor 568
  Secondary Antibody Dilution:
  1:400
  Color/Signal Descriptions:
  Red: CTPS2 Blue: DAPI
  Gene Name:
  CTPS2
  Submitted by:
  S. John Calise, Edward Chan Lab, University of Florida
• Image 2: Human HeLa
  
  WB Suggested Anti-CTPS2 Antibody
  Titration: 1.0 ug/ml
  Positive Control: Hela Whole CellCTPS2 is supported by BioGPS gene expression data to be expressed in HeLa