Product Number |
ARP61142_P050 |
Product Page |
www.avivasysbio.com/clu-antibody-c-terminal-region-arp61142-p050.html |
Name |
CLU Antibody - C-terminal region (ARP61142_P050) |
Protein Size (# AA) |
501 amino acids |
Molecular Weight |
58kDa |
NCBI Gene Id |
1191 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Clusterin |
Description |
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Alias Symbols |
CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-40, TRPM2, TRPM-2, NA1/NA2 |
Peptide Sequence |
Synthetic peptide located within the following region: CREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLN |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants. |
Protein Interactions |
HYOU1; HSP90B1; HSPA5; BAX; TUFM; NUCB2; HSPA1L; TUBB6; MDM2; FOS; CDK19; APOA1; KEAP1; POLR1C; RPL23; KLF11; BAG6; RBBP8; MAPK9; PDIA3; CYP2E1; BCL2L1; TSC22D4; MDC1; LIG4; PAXIP1; CLUAP1; IL24; PRNP; PON1; HSPD1; APP; FBXO6; LYZ; LRP2; HBA1; XRCC6; ELN; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
Relative Expression (Western Blot) |
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Datasheets/Manuals |
Printable datasheet for anti-CLU (ARP61142_P050) antibody |
Blocking Peptide |
For anti-CLU (ARP61142_P050) antibody is Catalog # AAP61142 (Previous Catalog # AAPP47252) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human CLU |
Uniprot ID |
P10909 |
Protein Name |
Clusterin |
Publications |
Clusterin secretion is attenuated by the proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in models of cartilage degradation. J Orthop Res. (2020) 32725904 |
Protein Accession # |
NP_001822 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_001831 |
Tested Species Reactivity |
Human, Horse |
Gene Symbol |
CLU |
Predicted Species Reactivity |
Human, Mouse, Rat, Guinea Pig, Horse, Rabbit |
Application |
WB, IHC |
Predicted Homology Based on Immunogen Sequence |
Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 91%; Rat: 86% |
Image 1 | Human Fetal Brain
| CLU antibody - C-terminal region (ARP61142_P050) validated by WB using Fetal Brain Lysate at 1ug/ml. |
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Image 2 | Human HK2
| Lanes: 1. 40 ug human HK2 cell (kidney proximal tubular cell line) lysate 2. 40 ug H2O2 treated human HK2 Cell lysate 3. 40 ug H2O2 treated human HK2 Cell lysate 4. 40 ug H2O2 treated human HK2 Cell lysate 5. 40 ug H2O2 treated human HK2 Cell lysate 6. 40 ug H2O2 treated human HK2 Cell lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Goat anti-Rabbit HRP Secondary Antibody Dilution: 1:2000 Gene Name: CLU Submitted by: The University of Queensland, School of Medicine, Centre for Kidney Disease Research
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Image 3 | Human heart
| Rabbit Anti-CLU Antibody Catalog Number: ARP61142_P050 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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Image 4 | Human liver tissue
| Rabbit Anti-CLU Antibody Catalog Number: ARP61142_P050 Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue Observed Staining: Cytoplasm in hepatocytes Primary Antibody Concentration: 1:100 Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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