| Product Number |
ARP61023_P050 |
| Product Page |
www.avivasysbio.com/cd44-antibody-c-terminal-region-arp61023-p050.html |
| Name |
CD44 Antibody - C-terminal region (ARP61023_P050) |
| Protein Size (# AA) |
361 amino acids |
| Molecular Weight |
40kDa |
| NCBI Gene Id |
960 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
CD44 molecule (Indian blood group) |
| Description |
|
| Alias Symbols |
IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III |
| Peptide Sequence |
Synthetic peptide located within the following region: SGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQN |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. |
| Protein Interactions |
UBC; NF2; NEDD8; BAG1; DPP8; VHL; SRC; ANK1; ATF2; FMNL1; IQGAP1; SLC3A2; STAT3; ITGB1; FLOT2; EP300; CAV1; PRKCZ; ELAVL1; ARHGEF12; ARHGEF1; PKN1; DMP1; HMMR; TIAM1; ERBB4; VAV2; GARS; TGFBR2; TGFBR1; CD4; MMP7; SRGN; SPP1; LCK; IGFBP3; CD74; FYN; FGF2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CD44 (ARP61023_P050) antibody |
| Blocking Peptide |
For anti-CD44 (ARP61023_P050) antibody is Catalog # AAP61023 (Previous Catalog # AAPP47152) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human CD44 |
| Uniprot ID |
P16070 |
| Protein Name |
CD44 antigen |
| Publications |
Monika Hartmann, et al. Tumor Suppressor NF2 Blocks Cellular Migration by Inhibiting Ectodomain Cleavage of CD44. 879-90 (2015). 25652588 |
| Sample Type Confirmation |
CD44 is strongly supported by BioGPS gene expression data to be expressed in MD-MB231 |
| Protein Accession # |
NP_001001391 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001001391 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CD44 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 79%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Fetal heart
 | WB Suggested Anti-CD44 Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Heart |
|
| Image 2 | Human MDA-MB231
 | Lane 1: 10ug MDA-MB-231 lysateLane 2: MDA-MB-231 + CD44 siRNA
Primary Antibody Dilution:
1:1000
Secondary Antibody:
Goat anti rabbit-HRP
Secondary Antibody Dilution:
1:10,000
Gene Name:
CD44
Submitted by:
Chul Geun Kim and Dae Hyun Ha, Hanyang University.CD44 is strongly supported by BioGPS gene expression data to be expressed in MDA-MB231 |
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