| Product Number |
ARP60360_P050 |
| Product Page |
www.avivasysbio.com/sh2d1a-antibody-middle-region-arp60360-p050.html |
| Name |
SH2D1A Antibody - middle region (ARP60360_P050) |
| Protein Size (# AA) |
125 amino acids |
| Molecular Weight |
13kDa |
| NCBI Gene Id |
4068 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Alias Symbols |
LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1, SAP/SH2D1A |
| Peptide Sequence |
Synthetic peptide located within the following region: YTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. |
| Protein Interactions |
LHX4; TNK2; UBC; LYN; MAPK11; MAPK1; ERBB3; EGFR; MAPK14; CD244; ELAVL1; SLAMF7; SLAMF6; ARHGEF7; CD84; SLAMF1; DOK1; FYB; LY9; ARHGEF6; LCK; FYN; GRB2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SH2D1A (ARP60360_P050) antibody |
| Blocking Peptide |
For anti-SH2D1A (ARP60360_P050) antibody is Catalog # AAP60360 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of Human SH2D1A |
| Uniprot ID |
O60880-4 |
| Protein Name |
SH2 domain-containing protein 1A |
| Purification |
Affinity Purified |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SH2D1A |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 90% |
| Image 1 | Human 293T
 | Host: Rabbit
Target Name: SH2D1A
Sample Type: 293T Whole Cell lysates
Antibody Dilution: 1.0ug/ml |
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