Product Number |
ARP60116_P050 |
Product Page |
www.avivasysbio.com/ctsc-antibody-middle-region-arp60116-p050.html |
Name |
CTSC Antibody - middle region (ARP60116_P050) |
Protein Size (# AA) |
463 amino acids |
Molecular Weight |
8kDa |
NCBI Gene Id |
1075 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Cathepsin C |
Description |
|
Alias Symbols |
JP, HMS, JPD, PLS, CPPI, DPP1, DPPI, PALS, DPP-I, PDON1 |
Peptide Sequence |
Synthetic peptide located within the following region: WTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTS |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. |
Protein Interactions |
SUMO1; UBC; NEDD8; ARMC9; ANKMY2; ARIH1; UBA2; ADSL; FBXO6; XRN2; CAPN1; CD81; CTSC; CTSL; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CTSC (ARP60116_P050) antibody |
Blocking Peptide |
For anti-CTSC (ARP60116_P050) antibody is Catalog # AAP60116 (Previous Catalog # AAPP46256) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human CTSC |
Uniprot ID |
P53634 |
Protein Name |
Dipeptidyl peptidase 1 |
Publications |
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. Cells. 8, (2019). 30818851 |
Protein Accession # |
NP_001805 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_001814 |
Tested Species Reactivity |
Human |
Gene Symbol |
CTSC |
Predicted Species Reactivity |
Human, Mouse, Cow, Dog, Horse |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 86%; Dog: 79%; Horse: 86%; Human: 100%; Mouse: 79% |
Image 1 | Human PANC1
| WB Suggested Anti-CTSC Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: PANC1 cell lysate |
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