Product Number |
ARP59998_P050 |
Product Page |
www.avivasysbio.com/col1a1-antibody-c-terminal-region-arp59998-p050.html |
Name |
COL1A1 Antibody - C-terminal region (ARP59998_P050) |
Protein Size (# AA) |
1464 amino acids |
Molecular Weight |
137kDa |
NCBI Gene Id |
1277 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Collagen, type I, alpha 1 |
Alias Symbols |
OI1, OI2, OI3, OI4, EDSC, CAFYD, EDSARTH1 |
Peptide Sequence |
Synthetic peptide located within the following region: YRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMC |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. |
Protein Interactions |
PDGFB; PDGFA; COL1A2; COL1A1; CAPN1; UBC; BRCA1; BARD1; C12orf57; RNH1; ATP13A2; ELAVL1; ACHE; TMPRSS6; P4HB; PAK1; HTRA1; MATN2; PRELP; TGFBI; BGN; VWF; ITGA2; DDR2; THBS1; TXN; SPARC; CD36; FGF7; IGFBP3; ITGA5; FN1; NID1; DCN; CD93; MMP9; MMP2; COL7A1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-COL1A1 (ARP59998_P050) antibody |
Blocking Peptide |
For anti-COL1A1 (ARP59998_P050) antibody is Catalog # AAP59998 (Previous Catalog # AAPP46152) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human COL1A1 |
Uniprot ID |
P02452 |
Protein Name |
Collagen alpha-1(I) chain |
Protein Accession # |
NP_000079 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000088 |
Tested Species Reactivity |
Human |
Gene Symbol |
COL1A1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92% |
Image 1 | Human Brain
| WB Suggested Anti-COL1A1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Human brain |
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Image 2 | Human Urinary Bladder
| Rabbit Anti-COL1A1 Antibody Catalog Number: ARP59998_P050 Formalin Fixed Paraffin Embedded Tissue: Human Urinary Bladder Tissue Observed Staining: Cytoplasm Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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