| Product Number |
ARP59350_P050 |
| Product Page |
www.avivasysbio.com/cops6-antibody-middle-region-arp59350-p050.html |
| Name |
COPS6 Antibody - middle region (ARP59350_P050) |
| Protein Size (# AA) |
327 amino acids |
| Molecular Weight |
36kDa |
| Subunit |
6 |
| NCBI Gene Id |
10980 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) |
| Alias Symbols |
CSN6, MOV34-34KD |
| Peptide Sequence |
Synthetic peptide located within the following region: DHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. |
| Protein Interactions |
NEDD8; CUL1; UBC; COPS5; GPS1; SUMO1; POP7; COPS7B; COPS7A; CUL4B; USP7; COPS4; FBXO6; FBXW4; IGHV3OR15-7; vpr; TP63; RFWD2; SFN; IRF5; COPS8; COPS2; COPS3; DDB2; DDB1; ERCC8; TOR1AIP2; LRR1; RBX1; VPRBP; LRRC14; CUL2; CUL3; CUL4A; CUL5; TCEB2; TCEB1; SKP |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-COPS6 (ARP59350_P050) antibody |
| Blocking Peptide |
For anti-COPS6 (ARP59350_P050) antibody is Catalog # AAP59350 (Previous Catalog # AAPP45447) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human COPS6 |
| Uniprot ID |
Q7L5N1 |
| Protein Name |
COP9 signalosome complex subunit 6 |
| Publications |
Pick, E. et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012). 22956996 |
| Sample Type Confirmation |
COPS6 is strongly supported by BioGPS gene expression data to be expressed in 721_B |
| Protein Accession # |
NP_006824 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_006833 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
COPS6 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93% |
| Image 1 | Human 721_B
 | WB Suggested Anti-COPS6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysateCOPS6 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
|
| Image 2 | Human, Mouse
 | Sample Type: 1. ABAE cells
2. CHO-IR cells
Primary Dilution: 1:200
Secondary Anitbody: HRP conjugated anti-rabbit
Image Submitted By: Dr. Elah Pick
University of Haifa at Oranim
|
|
| Image 3 | Human Testis
 | Rabbit Anti-COPS6 antibody
Catalog Number: ARP59350
Formalin Fixed Paraffin Embedded Tissue: Human Testis
Primary antibody Concentration: 1:100
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20x
Exposure Time: 0.5-2.0sec
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