CSTB Antibody - N-terminal region (ARP59177_P050)

Data Sheet
 
Product Number ARP59177_P050
Product Page www.avivasysbio.com/cstb-antibody-n-terminal-region-arp59177-p050.html
Name CSTB Antibody - N-terminal region (ARP59177_P050)
Protein Size (# AA) 98 amino acids
Molecular Weight 11kDa
NCBI Gene Id 1476
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Cystatin B (stefin B)
Alias Symbols PME, ULD, CST6, EPM1, STFB, CPI-B, EPM1A
Peptide Sequence Synthetic peptide located within the following region: ADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRV
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.
Protein Interactions UBC; SARNP; DPP7; BAG3; CFTR; ECT2; SEC24A; NUDC; MAT2A; FLNB; DCUN1D1; CUL3; RAD21; SPRY2; CTSL; CTSD; CTSH; CTSB; CST3; VHL;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CSTB (ARP59177_P050) antibody
Blocking Peptide For anti-CSTB (ARP59177_P050) antibody is Catalog # AAP59177 (Previous Catalog # AAPP45145)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CSTB
Uniprot ID P04080
Protein Name Cystatin-B
Protein Accession # NP_000091
Purification Affinity Purified
Nucleotide Accession # NM_000100
Tested Species Reactivity Human, Mouse
Gene Symbol CSTB
Predicted Species Reactivity Human, Rat, Cow, Horse, Pig, Sheep
Application WB, IHC
Predicted Homology Based on Immunogen Sequence Cow: 100%; Horse: 93%; Human: 100%; Pig: 92%; Rat: 75%; Sheep: 100%
Image 1
Human heart
Rabbit Anti-CSTB Antibody
Catalog Number: ARP59177_P050
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Cytoplasmic
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Image 2
Mouse
CSTB antibody - N-terminal region (ARP59177_P050) validated by WB using Mice brain lysate at 1:2,000.
Image 3
Human heart
WB Suggested Anti-CSTB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human heart
 

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