Product Number |
ARP59177_P050 |
Product Page |
www.avivasysbio.com/cstb-antibody-n-terminal-region-arp59177-p050.html |
Name |
CSTB Antibody - N-terminal region (ARP59177_P050) |
Protein Size (# AA) |
98 amino acids |
Molecular Weight |
11kDa |
NCBI Gene Id |
1476 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Cystatin B (stefin B) |
Alias Symbols |
PME, ULD, CST6, EPM1, STFB, CPI-B, EPM1A |
Peptide Sequence |
Synthetic peptide located within the following region: ADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy. |
Protein Interactions |
UBC; SARNP; DPP7; BAG3; CFTR; ECT2; SEC24A; NUDC; MAT2A; FLNB; DCUN1D1; CUL3; RAD21; SPRY2; CTSL; CTSD; CTSH; CTSB; CST3; VHL; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CSTB (ARP59177_P050) antibody |
Blocking Peptide |
For anti-CSTB (ARP59177_P050) antibody is Catalog # AAP59177 (Previous Catalog # AAPP45145) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CSTB |
Uniprot ID |
P04080 |
Protein Name |
Cystatin-B |
Protein Accession # |
NP_000091 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000100 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
CSTB |
Predicted Species Reactivity |
Human, Rat, Cow, Horse, Pig, Sheep |
Application |
WB, IHC |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Horse: 93%; Human: 100%; Pig: 92%; Rat: 75%; Sheep: 100% |
Image 1 | Human heart
| Rabbit Anti-CSTB Antibody Catalog Number: ARP59177_P050 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
|
Image 2 | Mouse
| CSTB antibody - N-terminal region (ARP59177_P050) validated by WB using Mice brain lysate at 1:2,000. |
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Image 3 | Human heart
| WB Suggested Anti-CSTB Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human heart |
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