| Product Number |
ARP58763_P050 |
| Product Page |
www.avivasysbio.com/shb-antibody-n-terminal-region-arp58763-p050.html |
| Name |
SHB Antibody - N-terminal region (ARP58763_P050) |
| Protein Size (# AA) |
509 amino acids |
| Molecular Weight |
55kDa |
| NCBI Gene Id |
6461 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Src homology 2 domain containing adaptor protein B |
| Alias Symbols |
bA3J10.2 |
| Peptide Sequence |
Synthetic peptide located within the following region: ERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAY |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Kriz,V., (2006) J. Biol. Chem. 281 (45), 34484-34491 |
| Description of Target |
SHB is the adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. SHB may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. SHB may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. SHB may also regulate IRS1 and IRS2 signaling in insulin-producing cells. |
| Protein Interactions |
SLC39A1; GRAP2; LAT; LCP2; EPS8; JAK3; IL2RG; KDR; SRC; ZAP70; PDGFRA; PLCG1; PIK3R1; VAV1; CRK; JAK1; IL2RB; GRB2; FGFR1; PDGFRB; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SHB (ARP58763_P050) antibody |
| Blocking Peptide |
For anti-SHB (ARP58763_P050) antibody is Catalog # AAP58763 (Previous Catalog # AAPP38530) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SHB |
| Uniprot ID |
Q15464 |
| Protein Name |
SH2 domain-containing adapter protein B |
| Sample Type Confirmation |
SHB is supported by BioGPS gene expression data to be expressed in HepG2 |
| Protein Accession # |
NP_003019 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003028 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SHB |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human HepG2
 | WB Suggested Anti-SHB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: HepG2 cell lysateSHB is supported by BioGPS gene expression data to be expressed in HepG2 |
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