| Product Number |
ARP58687_P050 |
| Product Page |
www.avivasysbio.com/uba1-antibody-n-terminal-region-arp58687-p050.html |
| Name |
UBA1 Antibody - N-terminal region (ARP58687_P050) |
| Protein Size (# AA) |
1058 amino acids |
| Molecular Weight |
116kDa |
| NCBI Gene Id |
7317 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Ubiquitin-like modifier activating enzyme 1 |
| Alias Symbols |
A1S9, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, VEXAS, CFAP124 |
| Peptide Sequence |
Synthetic peptide located within the following region: MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEPGRHPQAVAAV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Ramser,J., (2008) Am. J. Hum. Genet. 82 (1), 188-193 |
| Description of Target |
UBA1 activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. |
| Protein Interactions |
USP5; UBE2D2; UBC; FUS; ISG15; UBTD2; HUWE1; UBE2L3; UBE2D1; SUMO2; CDC34; UBE2K; UBE2W; UBE2R2; UBE2J1; UBE2T; UBE2S; UBE2C; UBE2E3; UBE2H; UBE2G2; UBE2G1; UBE2E2; UBE2E1; UBE2D3; UBE2B; UBE2A; UBI4; MDM2; TRIM25; XPNPEP1; EZR; MC1R; IPO5; FH; CTPS1; ATI |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-UBA1 (ARP58687_P050) antibody |
| Blocking Peptide |
For anti-UBA1 (ARP58687_P050) antibody is Catalog # AAP58687 (Previous Catalog # AAPP35934) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human UBA1 |
| Uniprot ID |
P22314 |
| Protein Name |
Ubiquitin-like modifier-activating enzyme 1 |
| Publications |
Rogers, L. M., Olivier, A. K., Meyerholz, D. K. & Dupuy, A. J. Adaptive immunity does not strongly suppress spontaneous tumors in a Sleeping Beauty model of cancer. J. Immunol. 190, 4393-9 (2013). 23475219 |
| Protein Accession # |
NP_003325 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003334 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
UBA1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human HepG2
 | WB Suggested Anti-UBA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: HepG2 cell lysate |
|
