| Product Number |
ARP58648_P050 |
| Product Page |
www.avivasysbio.com/ogdh-antibody-n-terminal-region-arp58648-p050.html |
| Name |
OGDH Antibody - N-terminal region (ARP58648_P050) |
| Protein Size (# AA) |
427 amino acids |
| Molecular Weight |
47kDa |
| NCBI Gene Id |
4967 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) |
| Alias Symbols |
E1k, KGD1, OGDC, AKGDH, OGDH2 |
| Peptide Sequence |
Synthetic peptide located within the following region: MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
van (2007) Am. J. Med. Genet. A 143 (7), 763-767 |
| Description of Target |
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitocondrial matrix and uses thiamine pyrophosphate as a cofactor. A congential deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. |
| Protein Interactions |
MDM2; UBC; SUMO1; NEDD8; CPSF7; MRPL38; MRPL41; TSR1; MRPS2; MRPL15; MRPL13; SCFD1; PDHX; SSBP1; SUMO2; PDHB; PDHA1; DLST; DLAT; DHODH; ISG15; USP13; PLSCR1; DLD; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-OGDH (ARP58648_P050) antibody |
| Blocking Peptide |
For anti-OGDH (ARP58648_P050) antibody is Catalog # AAP58648 (Previous Catalog # AAPP35785) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human OGDH |
| Uniprot ID |
Q96DD3 |
| Protein Name |
2-oxoglutarate dehydrogenase, mitochondrial |
| Protein Accession # |
NP_001003941 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001003941 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
OGDH |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93% |
| Image 1 | Human DLD1
 | Host: Rabbit
Target Name: OGDH
Sample Tissue: Human DLD1
Antibody Dilution: 1.0ug/ml |
|
| Image 2 | MCF7, 293T
 | Host: Rabbit
Target: OGDH
Positive control (+): MCF7 (N10)
Negative control (-): 293T (2T)
Antibody concentration: 1ug/ml |
|
