| Product Number |
ARP58642_P050 |
| Product Page |
www.avivasysbio.com/mvp-antibody-n-terminal-region-arp58642-p050.html |
| Name |
MVP Antibody - N-terminal region (ARP58642_P050) |
| Protein Size (# AA) |
893 amino acids |
| Molecular Weight |
98kDa |
| NCBI Gene Id |
9961 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Major vault protein |
| Alias Symbols |
LRP, VAULT1 |
| Peptide Sequence |
Synthetic peptide located within the following region: MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRM |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
de (2008) Cytometry B Clin Cytom 74 (3), 163-168 |
| Description of Target |
MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. |
| Protein Interactions |
MVP; SKIL; TRIM27; REL; PLSCR1; MEOX2; MEOX1; MDFI; KPNA3; GOLGA2; DLX2; CAMK2B; AES; TRIP6; TRAF2; TP53; TFCP2; TCF4; SUMO2; NOTCH2NL; CCDC36; TRIM42; FAM154A; PIH1D2; RAB3IP; RIMBP3; C1orf94; RHOXF2; ZMIZ2; OBFC1; RFWD2; MKL1; VAC14; BANP; FAM46C; KCTD9 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-MVP (ARP58642_P050) antibody |
| Blocking Peptide |
For anti-MVP (ARP58642_P050) antibody is Catalog # AAP58642 (Previous Catalog # AAPP35779) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human MVP |
| Uniprot ID |
Q14764 |
| Protein Name |
Major vault protein |
| Protein Accession # |
NP_005106 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_005115 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
MVP |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86% |
| Image 1 | Human COLO205
 | WB Suggested Anti-MVP Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: COLO205 cell lysate |
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