Product Number |
ARP58570_P050 |
Product Page |
www.avivasysbio.com/ercc8-antibody-middle-region-arp58570-p050.html |
Name |
ERCC8 Antibody - middle region (ARP58570_P050) |
Protein Size (# AA) |
396 amino acids |
Molecular Weight |
44kDa |
NCBI Gene Id |
1161 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Excision repair cross-complementing rodent repair deficiency, complementation group 8 |
Alias Symbols |
CSA, CKN1, UVSS2 |
Peptide Sequence |
Synthetic peptide located within the following region: FQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEE |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Bethke,L., (2008) J. Natl. Cancer Inst. 100 (4), 270-276 |
Description of Target |
ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. |
Protein Interactions |
CUL4A; CUL4B; DDB1; RUVBL2; ZNF24; PCNA; H1F0; ERCC6; UVSSA; DDA1; RFWD2; COPS4; COPS6; COPS3; TOP1; TP53; SSBP1; OGG1; MDM2; GTF2H2; CUL5; GPS1; DDB2; COPS2; COPS7A; COPS5; COPS8; RBX1; POLR2A; HMGN1; EP300; UBC; CSNK2B; XAB2; UQCRQ; CBR1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-ERCC8 (ARP58570_P050) antibody |
Blocking Peptide |
For anti-ERCC8 (ARP58570_P050) antibody is Catalog # AAP58570 (Previous Catalog # AAPP35516) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human ERCC8 |
Uniprot ID |
Q13216 |
Protein Name |
DNA excision repair protein ERCC-8 |
Sample Type Confirmation |
ERCC8 is supported by BioGPS gene expression data to be expressed in HepG2 |
Protein Accession # |
NP_000073 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000082 |
Tested Species Reactivity |
Human |
Gene Symbol |
ERCC8 |
Predicted Species Reactivity |
Human |
Application |
WB |
Image 1 | Human HepG2
| WB Suggested Anti-ERCC8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysateERCC8 is supported by BioGPS gene expression data to be expressed in HepG2 |
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