| Product Number |
ARP58562_P050 |
| Product Page |
www.avivasysbio.com/lrp1-antibody-middle-region-arp58562-p050.html |
| Name |
LRP1 Antibody - middle region (ARP58562_P050) |
| Protein Size (# AA) |
439 amino acids |
| Molecular Weight |
48kDa |
| NCBI Gene Id |
4035 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Low density lipoprotein receptor-related protein 1 |
| Alias Symbols |
APR, KPA, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R, IGFBP-3R, IGFBP3R1 |
| Peptide Sequence |
Synthetic peptide located within the following region: ATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCAR |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
Low-density lipoprotein receptor-related protein 1 (.-2-macroglobulin receptor, LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in the extracellular matrix. It is also involved in intracellular signaling and the subcellular translocation of preassembled signaling complexes from the plasma membrane. |
| Protein Interactions |
UBC; COPS5; APP; RANBP9; SKIL; CHFR; CUBN; FBXO6; ANKS1B; RIC8B; PID1; CC2D1A; MAPRE1; HNRNPDL; MAPK8IP1; SNRNP70; APOE; CACNA1A; USP3; CAV1; MMP14; SHC1; MMP13; SERPINA1; F9; F8; LPL; HSP90B1; SRC; PDGFB; THBS1; SCN3A; PLAUR; PLAT; SERPINE1; MDK; LIPC; L |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-LRP1 (ARP58562_P050) antibody |
| Blocking Peptide |
For anti-LRP1 (ARP58562_P050) antibody is Catalog # AAP58562 (Previous Catalog # AAPP35508) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human LRP1 |
| Uniprot ID |
Q07954 |
| Protein Name |
Prolow-density lipoprotein receptor-related protein 1 |
| Publications |
Behl, M., Zhang, Y., Monnot, A. D., Jiang, W. & Zheng, W. Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1. Toxicol. Appl. Pharmacol. 240, 245-54 (2009). 19501112
Gu, H. et al. Lead exposure increases levels of beta-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice. Neurosci. Lett. 490, 16-20 (2011). 21167913
Hentschke, M. R. et al. Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. J. Lipid Res. 54, 2658-64 (2013). 23898049 |
| Protein Accession # |
AAH21204 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002332 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
LRP1 |
| Predicted Species Reactivity |
Human |
| Application |
IHC, WB |
| Image 1 | Human 721_B
 | WB Suggested Anti-LRP1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: 721_B cell lysate |
|
| Image 2 | Human placenta
 | Lanes:
Human placenta Primary Antibody Dilution:
1:500 Secondary Antibody:
Anti-rabbit-HRP Secondary Antibody Dilution:
1:5000 Gene Name:
Brown: LRP1 Purple: Haemotoxylin Submitted by:
LRP1 |
|
