| Product Number |
ARP58516_P050 |
| Product Page |
www.avivasysbio.com/ppp4c-antibody-middle-region-arp58516-p050.html |
| Name |
PPP4C Antibody - middle region (ARP58516_P050) |
| Protein Size (# AA) |
307 amino acids |
| Molecular Weight |
34kDa |
| NCBI Gene Id |
5531 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Protein phosphatase 4, catalytic subunit |
| Alias Symbols |
PP4, PPX, PP-X, PP4C, PPH3, PPP4 |
| Peptide Sequence |
Synthetic peptide located within the following region: TVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Humphray,S.J., (2008) J. Cell Biol. 180 (6), 1133-1147 |
| Description of Target |
PPP4C is a protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase. |
| Protein Interactions |
SUMO2; IKBKG; MAP4K1; BAG6; TCP1; UBC; CAND1; CUL3; Igbp1; TRIM28; ELAVL1; TK1; PPP2R5D; PPP2R4; PPP2R2B; PPP2R1A; EEF1A1; CCT6A; SMEK2; PPP2R2D; SMEK1; ATAD3A; PPME1; CCT5; CCT8; CCT2; CCT4; CCT7; PPP4R1; PLOD3; CCDC6; TUBA3C; CCT3; CCT6P1; GLYATL3; PPP4 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PPP4C (ARP58516_P050) antibody |
| Blocking Peptide |
For anti-PPP4C (ARP58516_P050) antibody is Catalog # AAP58516 (Previous Catalog # AAPP34724) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PPP4C |
| Uniprot ID |
P60510 |
| Protein Name |
Serine/threonine-protein phosphatase 4 catalytic subunit |
| Protein Accession # |
NP_002711 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002720 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PPP4C |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 100% |
| Image 1 | Human Muscle
 | WB Suggested Anti-PPP4C Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Muscle |
|
