G6PD Antibody - middle region (ARP58469_P050)

• Product Number: ARP58469_P050
• Name: G6PD Antibody - middle region (ARP58469_P050)
• Protein Size (# AA): 515 amino acids
• Molecular Weight: 57kDa
• NCBI Gene Id: 2539
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Glucose-6-phosphate dehydrogenase
• Alias Symbols: G6PD1
• Peptide Sequence: Synthetic peptide located within the following region: VTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRI
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Langbein,S., (2008) Int. J. Cancer 122 (11), 2422-2428
• Description of Target: G6PD is a glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.
• Protein Interactions: G6PD; SUMO2; UBC; MDM2; CKB; CAPN1; ALDH7A1; ZNF622; ZFYVE19; UBFD1; CNDP2; ISOC1; MAT2B; ERP44; YWHAQ; SLC9A3R1; YWHAZ; YWHAH; YWHAG; YWHAE; YWHAB; EIF4H; VCL; UBE2V1; TGM2; PPP1R2; PGD; PAK2; LDHB; SFN; GNS; GLA; GBP2; EIF5; BAG3; FN1; CCT4; HARS; SUMO4
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-G6PD (ARP58469_P050) antibody is Catalog # AAP58469 (Previous Catalog # AAPP34520)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human G6PD
• Uniprot ID: P11413
• Protein Name: Glucose-6-phosphate 1-dehydrogenase
• Sample Type Confirmation:

  G6PD is supported by BioGPS gene expression data to be expressed in MCF7

• Protein Accession #: NP_000393
• Purification: Affinity Purified
• Nucleotide Accession #: NM_000402
• Tested Species Reactivity: Human
• Gene Symbol: G6PD
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 85%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 86%; Sheep: 83%
• Image 1: Human MCF7
  
  WB Suggested Anti-G6PD Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:62500
  Positive Control: MCF7 cell lysateG6PD is supported by BioGPS gene expression data to be expressed in MCF7
• Image 2: Human Fetal Lung
  
  Host: Rabbit
  Target Name: NSUN6
  Sample Type: Human Fetal Lung
  Antibody Dilution: 1.0ug/ml