| Product Number |
ARP58450_P050 |
| Product Page |
www.avivasysbio.com/dctn2-antibody-n-terminal-region-arp58450-p050.html |
| Name |
DCTN2 Antibody - N-terminal region (ARP58450_P050) |
| Protein Size (# AA) |
406 amino acids |
| Molecular Weight |
45kDa |
| Subunit |
2 |
| NCBI Gene Id |
10540 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Dynactin 2 (p50) |
| Alias Symbols |
RBP50, DCTN50, HEL-S-77, DYNAMITIN |
| Peptide Sequence |
Synthetic peptide located within the following region: ADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELTSTSVEHI |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Camargo,L.M., (2007) Mol. Psychiatry 12 (1), 74-86 |
| Description of Target |
DCTN2 is a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
KIFC3; CCDC172; HAUS1; BLOC1S6; DCTN2; BICD2; DYNC1I1; DCTN1; UBC; FLNB; NUP43; LEO1; SEH1L; ACTR10; DCTN4; DCTN3; ACTR1A; ACTR1B; RABEP1; LMNB1; GADD45A; KPNA2; SMURF1; DYNLRB1; STRN4; RANBP9; TPM4; SNRPA1; PSMD4; PSMD1; PSMC4; PSMC2; POLR2D; POLR2A; MCM |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-DCTN2 (ARP58450_P050) antibody |
| Blocking Peptide |
For anti-DCTN2 (ARP58450_P050) antibody is Catalog # AAP58450 (Previous Catalog # AAPP34559) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human DCTN2 |
| Uniprot ID |
Q13561 |
| Protein Name |
Dynactin subunit 2 |
| Protein Accession # |
NP_006391 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_006400 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
DCTN2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-DCTN2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Jurkat cell lysate |
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