| Product Number |
ARP58434_P050 |
| Product Page |
www.avivasysbio.com/capns1-antibody-middle-region-arp58434-p050.html |
| Name |
CAPNS1 Antibody - middle region (ARP58434_P050) |
| Protein Size (# AA) |
268 amino acids |
| Molecular Weight |
29kDa |
| Subunit |
1 |
| NCBI Gene Id |
826 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Calpain, small subunit 1 |
| Alias Symbols |
CANP, CDPS, CSS1, CANPS, CAPN4, CALPAIN4 |
| Peptide Sequence |
Synthetic peptide located within the following region: RRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. |
| Protein Interactions |
AGTRAP; HUWE1; NEDD1; TUBGCP2; TUBGCP3; CDC20; UBC; OGFOD1; STK26; ISOC1; DCPS; MAT2B; PROSC; FERMT2; YWHAQ; PDIA4; YWHAZ; YWHAH; YWHAG; YWHAE; PTMA; PPP1CA; PAK2; PAFAH1B1; MYO1E; MAT2A; GNAI3; GAPDH; EIF5; TBCB; ALDH7A1; ASNS; APEX1; ADRB2; PPARGC1A; VC |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CAPNS1 (ARP58434_P050) antibody |
| Blocking Peptide |
For anti-CAPNS1 (ARP58434_P050) antibody is Catalog # AAP58434 (Previous Catalog # AAPP34805) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human CAPNS1 |
| Uniprot ID |
P04632 |
| Protein Name |
Calpain small subunit 1 |
| Publications |
Kulkarni, Y. M. et al. Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis. Analyst 138, 6986-96 (2013). 24091439 |
| Protein Accession # |
NP_001003962 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001003962 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CAPNS1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100% |
| Image 1 | Human Lung
 | WB Suggested Anti-CAPNS1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Lung |
|
