| Product Number |
ARP58353_P050 |
| Product Page |
www.avivasysbio.com/usp22-antibody-middle-region-arp58353-p050.html |
| Name |
USP22 Antibody - middle region (ARP58353_P050) |
| Protein Size (# AA) |
525 amino acids |
| Molecular Weight |
60kDa |
| NCBI Gene Id |
23326 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Ubiquitin specific peptidase 22 |
| Alias Symbols |
USP3L |
| Peptide Sequence |
Synthetic peptide located within the following region: PSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Zhang,X.Y., (2008) Mol. Cell 29 (1), 102-111 |
| Description of Target |
USP22 is a subunit of the SAGA transcriptional cofactor complex. It deubiquitylates histone H2B and is recruited to specific genes by activators like Myc. USP22 is needed for cell cycle progression. It deubiquitylates histone H2A in addition to H2B. Altered mRNA expression is associated with therapy failure and death in patients multiple types of cancer. |
| Protein Interactions |
UBC; AASDHPPT; STAT3; TAF10; TADA2A; ATXN7; MYC; KAT2A; TRRAP; TAF9B; HIST1H2BD; TADA3; SUMO1; NFATC2; SIRT1; ATXN7L3; FUBP1; HIST2H2BE; HIST2H2AC; MRPL44; ATXN7L3B; USP27X; KIF7; KLHL23; ATXN7L2; TADA1; CCDC101; TADA2B; ENY2; SUPT20H; TAF5L; SND1; CNOT10 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-USP22 (ARP58353_P050) antibody |
| Blocking Peptide |
For anti-USP22 (ARP58353_P050) antibody is Catalog # AAP58353 (Previous Catalog # AAPP32963) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human USP22 |
| Uniprot ID |
Q9UPT9 |
| Protein Name |
Ubiquitin carboxyl-terminal hydrolase 22 |
| Protein Accession # |
NP_056091 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_015276 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
USP22 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93% |
| Image 1 | Human Fetal Heart
 | Host: Rabbit
Target Name: USP22
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml |
|
| Image 2 | Human Fetal Liver
 | Host: Rabbit
Target Name: USP22
Sample Type: Human Fetal Liver
Antibody Dilution: 1.0ug/ml |
|
| Image 3 | Human Fetal Lung
 | Host: Rabbit
Target Name: USP22
Sample Type: Human Fetal Lung
Antibody Dilution: 1.0ug/ml |
|
| Image 4 | Human Heart
 | WB Suggested Anti-USP22 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human heart |
|
