| Product Number |
ARP57949_P050 |
| Product Page |
www.avivasysbio.com/snf8-antibody-c-terminal-region-arp57949-p050.html |
| Name |
SNF8 Antibody - C-terminal region (ARP57949_P050) |
| Protein Size (# AA) |
258 amino acids |
| Molecular Weight |
29kDa |
| NCBI Gene Id |
11267 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) |
| Alias Symbols |
Dot3, EAP30, VPS22 |
| Peptide Sequence |
Synthetic peptide located within the following region: QVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEITAEEAREALP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Malerod,L., (2007) Traffic 8 (11), 1617-1629 |
| Description of Target |
ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor. SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM]. |
| Protein Interactions |
GOLGA2; VPS25; TRIM54; VAC14; UBC; BCAT1; SUV39H2; ACBD3; DUS3L; WDR12; PRMT6; RPUSD2; KDM1A; EFTUD2; TTC1; HARS; GTF2F1; GTF2E1; ELL; RBP1; MCM2; ADORA1; METTL14; NUDCD3; RILP; VPS36; CHMP6; VPS28; SNF8; TSG101; VPS20; NIF3L1; DVL2; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SNF8 (ARP57949_P050) antibody |
| Blocking Peptide |
For anti-SNF8 (ARP57949_P050) antibody is Catalog # AAP57949 (Previous Catalog # AAPP32360) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human SNF8 |
| Uniprot ID |
Q96H20 |
| Protein Name |
Vacuolar-sorting protein SNF8 |
| Protein Accession # |
NP_009172 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_007241 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SNF8 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 93% |
| Image 1 | Human HeLa
 | WB Suggested Anti-SNF8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Hela cell lysate |
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