| Product Number |
ARP56117_P050 |
| Product Page |
www.avivasysbio.com/pms2-antibody-middle-region-arp56117-p050.html |
| Name |
PMS2 Antibody - middle region (ARP56117_P050) |
| Protein Size (# AA) |
862 amino acids |
| Molecular Weight |
96kDa |
| NCBI Gene Id |
5395 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
PMS2 postmeiotic segregation increased 2 (S. cerevisiae) |
| Alias Symbols |
MLH4, PMSL2, HNPCC4, MMRCS4, PMS2CL |
| Peptide Sequence |
Synthetic peptide located within the following region: INKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Jackson,C.C., (2008) Pediatr Blood Cancer 50 (6), 1268-1270 |
| Description of Target |
PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. |
| Protein Interactions |
UBC; MLH1; PCNA; PMS2P1; NSF; MSH2; LMNA; MSH6; SPRTN; BRIP1; FAN1; CLSPN; TOPBP1; PSD2; MMS19; ATAD3A; NSUN2; UBR5; COPG2; PSD3; COPG1; RUVBL2; EXO1; AIFM1; RUVBL1; XPO1; SMARCA4; RFC2; PSMD5; PSMC6; PSMC3; PSMC2; PSMC1; PRKDC; PPP2CA; PIK3C2A; MSH3; MCM |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-PMS2 (ARP56117_P050) antibody |
| Blocking Peptide |
For anti-PMS2 (ARP56117_P050) antibody is Catalog # AAP56117 (Previous Catalog # AAPP37738) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human PMS2 |
| Uniprot ID |
P54278 |
| Protein Name |
Mismatch repair endonuclease PMS2 |
| Sample Type Confirmation |
PMS2 is supported by BioGPS gene expression data to be expressed in HepG2 |
| Protein Accession # |
NP_000526 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_000535 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
PMS2 |
| Predicted Species Reactivity |
Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 85%; Dog: 92%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Rabbit: 92%; Rat: 92%; Yeast: 91% |
| Image 1 | human
 | Sample Type: HeLa extractDilution: 1:1000 |
|
| Image 2 | Human HepG2
 | WB Suggested Anti-PMS2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysatePMS2 is supported by BioGPS gene expression data to be expressed in HepG2 |
|
