Product Number |
ARP56082_P050 |
Product Page |
www.avivasysbio.com/ndp-antibody-middle-region-arp56082-p050.html |
Name |
NDP Antibody - middle region (ARP56082_P050) |
Protein Size (# AA) |
133 amino acids |
Molecular Weight |
15kDa |
NCBI Gene Id |
4693 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Norrie disease (pseudoglioma) |
Alias Symbols |
ND, EVR2, FEVR |
Peptide Sequence |
Synthetic peptide located within the following region: DPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTV |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Khan,A.O., (2008) Ophthalmology 115 (4), 730-733 |
Description of Target |
NDP activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. NDP plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. NDP acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). NDP may be involved in a pathway that regulates neural cell differentiation and proliferation. NDP is the genetic locus identified as harboring mutations that result in Norrie disease. Norrie disease is a rare genetic disorder characterized by bilateral congenital blindness that is caused by a vascularized mass behind each lens due to a maldeveloped retina (pseudoglioma). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-94 AL034370.1 53727-53820 c 95-1761 X65882.1 1-1667 1762-1935 BE139596.1 1-174 c |
Protein Interactions |
FZD4; NDP; BAG3; APP; LGALS8; PPP1CA; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Enhanced Validation |
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Datasheets/Manuals |
Printable datasheet for anti-NDP (ARP56082_P050) antibody |
Blocking Peptide |
For anti-NDP (ARP56082_P050) antibody is Catalog # AAP56082 (Previous Catalog # AAPP37547) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human NDP |
Uniprot ID |
Q00604 |
Protein Name |
Norrin |
Protein Accession # |
NP_000257 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000266 |
Tested Species Reactivity |
Human |
Gene Symbol |
NDP |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
Application |
IHC, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
Image 1 | Human Liver
| WB Suggested Anti-NDP Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Liver |
| Image 2 | Human brain
| Immunohistochemistry with Brain, cortex tissue at an antibody concentration of 5ug/ml using anti-NDP antibody (ARP56082_P050) |
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