| Product Number |
ARP56008_P050 |
| Product Page |
www.avivasysbio.com/herv-frd-antibody-n-terminal-region-arp56008-p050.html |
| Name |
HERV-FRD Antibody - N-terminal region (ARP56008_P050) |
| Protein Size (# AA) |
538 amino acids |
| Molecular Weight |
60kDa |
| NCBI Gene Id |
405754 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Endogenous retrovirus group FRD, member 1 |
| Description |
|
| Alias Symbols |
envFRD, UNQ6191, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD |
| Peptide Sequence |
Synthetic peptide located within the following region: TGSPYSTNCWLCTSSSTETPGTAYPASPREWTSIEAELHISYRWDPNLKG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Malassine,A., (er) Retrovirology 5, 6 (2008) |
| Description of Target |
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. HERV-FRD can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.Human endogenous retroviruses (HERVs) make up approximately 8% of the human genome. Although most HERVs are nonfunctional, the HERV-W (ERVWE1; MIM 604659) and HERV-FRD envelope (env) proteins can induce cell-cell fusion when expressed in cells possessing appropriate receptors (Blaise et al., 2003 [PubMed 14557543]).[supplied by OMIM]. |
| Protein Interactions |
APP; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ERVFRD-1 (ARP56008_P050) antibody |
| Blocking Peptide |
For anti-ERVFRD-1 (ARP56008_P050) antibody is Catalog # AAP56008 (Previous Catalog # AAPP37414) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human HERV-FRD |
| Uniprot ID |
P60508 |
| Protein Name |
HERV-FRD_6p24.1 provirus ancestral Env polyprotein |
| Publications |
OVO-like 1 regulates progenitor cell fate in human trophoblast development. Proc Natl Acad Sci U S A. 112, E6175-84 (2015). 26504231 |
| Protein Accession # |
NP_997465 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_207582 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
ERVFRD-1 |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100% |
| Image 1 | Human PANC1 Whole Cell
 | Host: Rabbit
Target Name: ERVFRD-1
Sample Tissue: Human PANC1 Whole Cell
Antibody Dilution: 5ug/ml |
|
| Image 2 | Human PANC1
 | Host: Rabbit
Target Name: HERV
Sample Tissue: Human PANC1
Antibody Dilution: 1.0ug/ml |
|
| Image 3 | Human A549 Whole Cell
 | Host: Rabbit
Target Name: ERVFRD-1
Sample Tissue: Human A549 Whole Cell
Antibody Dilution: 1ug/ml |
|
