| Product Number |
ARP52398_P050 |
| Product Page |
www.avivasysbio.com/cry2-antibody-n-terminal-region-arp52398-p050.html |
| Name |
CRY2 Antibody - N-terminal region (ARP52398_P050) |
| Protein Size (# AA) |
593 amino acids |
| Molecular Weight |
67kDa |
| NCBI Gene Id |
1408 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Cryptochrome 2 (photolyase-like) |
| Alias Symbols |
HCRY2, PHLL2 |
| Peptide Sequence |
Synthetic peptide located within the following region: IELNGQKPPLTYKRFQAIISRMELPKKPVGLVTSQQMESCRAEIQENHDE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
CRY2 is a blue light-dependent regulator of the circadian feedback loop.CRY2 inhibits CLOCK NPAS2-ARNTL E box-mediated transcription. CRY2 acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity.CRY2 has no photolyase activity. CRY2 is capable of translocating circadian clock core proteins such as PER proteins to the nucleus.CRY2 may inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. |
| Protein Interactions |
MTUS2; PDE9A; CTBP1; UBC; FBXL3; FBXL21; BTRC; CUL1; SKP1; ATXN1; Csnk1e; PER3; PER2; PER1; PPP5C; TTC1; CRY2; TIMELESS; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CRY2 (ARP52398_P050) antibody |
| Blocking Peptide |
For anti-CRY2 (ARP52398_P050) antibody is Catalog # AAPP14342 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CRY2 |
| Uniprot ID |
Q49AN0 |
| Protein Name |
Cryptochrome-2 |
| Publications |
Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles. Proc. Natl. Acad. Sci. U.S.A. 113, 6053-8 (2016). 27166423 |
| Protein Accession # |
NP_066940 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_021117 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CRY2 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
| Application |
WB, IHC |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86% |
| Image 1 | Human U937
 | WB Suggested Anti-CRY2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: U937 cell lysate |
|
| Image 2 | Human Placenta, HepG2 Cell Lysate
 | Host: Rabbit
Target: CRY2
Positive control (+): Human Placenta (PL)
Negative control (-): HepG2 Cell Lysate (HG)
Antibody concentration: 1ug/ml |
|
| Image 3 | Human RPMI 8226 Whole Cell
 | Host: Rabbit
Target Name: CRY2
Sample Tissue: Human RPMI 8226 Whole Cell
Antibody Dilution: 1ug/ml |
|
| Image 4 | Human heart
 | Rabbit Anti-CRY2 Antibody
Catalog Number: ARP52398_P050
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Cytoplasmic
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec |
|
