| Product Number |
ARP52242_P050-HRP |
| Product Page |
www.avivasysbio.com/cops8-antibody-middle-region-hrp-arp52242-p050-hrp.html |
| Name |
COPS8 Antibody - middle region : HRP (ARP52242_P050-HRP) |
| Protein Size (# AA) |
209 amino acids |
| Molecular Weight |
23kDa |
| Subunit |
8 |
| Conjugation |
HRP: Horseradish Peroxidase |
| NCBI Gene Id |
10920 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) |
| Alias Symbols |
COP9, CSN8, SGN8 |
| Peptide Sequence |
Synthetic peptide located within the following region: TRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLE |
| Product Format |
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
| Description of Target |
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Protein Interactions |
USHBP1; GPS1; cul1; WDR77; SRRT; COPS7A; VIM; COPS4; FBXO6; FBXW4; COPS5; vpr; IRF5; DDIT3; COPS2; COPS3; COPS6; PINK1; RFWD2; CUL4A; UBC; LRR1; DDA1; DDB2; DCUN1D1; VPRBP; CUL2; CUL3; CUL4B; CUL5; NEDD8; JUN; GFER; ERCC8; DDB1; CTNNB1; RAE1; COPS8; EIF3E |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-COPS8 (ARP52242_P050-HRP) antibody |
| Blocking Peptide |
For anti-COPS8 (ARP52242_P050-HRP) antibody is Catalog # AAP52242 (Previous Catalog # AAPP44002) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human COPS8 |
| Uniprot ID |
Q99627 |
| Protein Name |
COP9 signalosome complex subunit 8 |
| Publications |
Pick, E. et al. The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One 7, e43980 (2012). WB, Bovine, Human, Rat, Horse, Rabbit, Guinea pig, Dog, Mouse 22956996 |
| Sample Type Confirmation |
There is BioGPS gene expression data showing that COPS8 is expressed in HepG2 |
| Protein Accession # |
NP_006701 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_006710 |
| Gene Symbol |
COPS8 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB, IHC |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | |
