| Product Number |
ARP52021_P050 |
| Product Page |
www.avivasysbio.com/clk1-antibody-n-terminal-region-arp52021-p050.html |
| Name |
CLK1 Antibody - N-terminal region (ARP52021_P050) |
| Protein Size (# AA) |
484 amino acids |
| Molecular Weight |
57kDa |
| NCBI Gene Id |
1195 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
CDC-like kinase 1 |
| Description |
|
| Alias Symbols |
CLK, STY, CLK/STY |
| Peptide Sequence |
Synthetic peptide located within the following region: HSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGC |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Protein Interactions |
KRTAP10-7; PDE9A; PRMT5; SRPK2; SRPK1; CLK1; BAG3; PIAS4; ISG15; UBC; YWHAG; LUC7L3; PPIG; SRSF6; PRPF4; GOLM1; UBL5; SRSF1; PTPN1; MBP; BCLAF1; NCOR1; SRSF3; SAFB; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CLK1 (ARP52021_P050) antibody |
| Blocking Peptide |
For anti-CLK1 (ARP52021_P050) antibody is Catalog # AAP52021 (Previous Catalog # AAPP44291) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CLK1 |
| Uniprot ID |
P49759 |
| Protein Name |
Dual specificity protein kinase CLK1 |
| Publications |
Eisenreich, A. et al. Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells. Oncol. Rep. 30, 462-70 (2013). 23604472
Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol. Cell. 63, 218-28 (2016). 27397683 |
| Sample Type Confirmation |
CLK1 is supported by BioGPS gene expression data to be expressed in HEK293T |
| Protein Accession # |
NP_004062 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_004071 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CLK1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 85% |
| Image 1 | Human HMEC-1
 | Sample type: human microvascular endothelial cells (25ug)
Primary Dilution: 1:1000
Secondary Antibody: Goat anti-Rabbit-HRP
Secondary Dilution: 1:5000
Image Submitted by: Andreas Eisenreich
Charite Universitatsmedizin Berlin |
|
| Image 2 | Human 293T
 | WB Suggested Anti-CLK1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysateCLK1 is supported by BioGPS gene expression data to be expressed in HEK293T |
|
