DCK Antibody - middle region (ARP51775_P050)

• Product Number: ARP51775_P050
• Name: DCK Antibody - middle region (ARP51775_P050)
• Protein Size (# AA): 260 amino acids
• Molecular Weight: 30kDa
• NCBI Gene Id: 1633
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Deoxycytidine kinase
• Alias Symbols: MGC117410, MGC138632
• Peptide Sequence: Synthetic peptide located within the following region: ATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQ
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Iyidogan,P. (2008) Biochemistry 47 (16), 4711-4720
• Description of Target: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Protein Interactions: UBC; EFHD2; CHRAC1; CHMP4A; CBX3; TYMS; THOP1; TALDO1; RBBP7; RANBP1; PTMS; IDH1; HSPE1; ADSS; TFEC; ELAVL1; RXRG; DCK; MED19; GOLM1; DDX19B;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-DCK (ARP51775_P050) antibody is Catalog # AAP51775 (Previous Catalog # AAPY03509)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DCK
• Uniprot ID: P27707
• Protein Name: Deoxycytidine kinase
• Publications:

  Bieghs, L. et al. The effects of forodesine in murine and human multiple myeloma cells. Adv. Hematol. 2010, 131895 (2010). 20981156

• Protein Accession #: NP_000779
• Purification: Affinity Purified
• Nucleotide Accession #: NM_000788
• Tested Species Reactivity: Human
• Gene Symbol: DCK
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%; Zebrafish: 93%
• Image 1: Human Heart
  
  WB Suggested Anti-DCK Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:62500
  Positive Control: Human heart
• Image 2: Human Placenta, Human Fetal Heart
  
  Host: Rabbit
  Target: DCK
  Positive control (+): Human Placenta (PL)
  Negative control (-): Human Fetal Heart (HE)
  Antibody concentration: 3ug/ml