FZR1 Antibody - N-terminal region : Biotin (ARP51279_P050-Biotin)

Data Sheet
 
Product Number ARP51279_P050-Biotin
Product Page www.avivasysbio.com/fzr1-antibody-n-terminal-region-biotin-arp51279-p050-biotin.html
Name FZR1 Antibody - N-terminal region : Biotin (ARP51279_P050-Biotin)
Protein Size (# AA) 493 amino acids
Molecular Weight 55kDa
Conjugation Biotin
NCBI Gene Id 51343
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Fizzy/cell division cycle 20 related 1 (Drosophila)
Alias Symbols FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C
Peptide Sequence Synthetic peptide located within the following region: SSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDN
Product Format Liquid. Purified antibody supplied in 1x PBS buffer.
Description of Target FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Protein Interactions ZC3HC1; CDC25A; CCNB1; UBE2S; UBE2C; PTTG1; UBE2D2; TP53; CDR2; UBE2K; ANAPC4; PDS1; STAU1; CDK2; CDC27; RACGAP1; FOXM1; HECW2; PHF8; BTRC; CCNA1; UBC; SOX2; SKP2; PLK1; CUL1; CUEDC2; CDC20; kif22; SIRT2; CLSPN; ANAPC11; CDC14B; VHL; PTEN; EYA1; DAXX; BUB
Reconstitution and Storage All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Datasheets/Manuals Printable datasheet for anti-FZR1 (ARP51279_P050-Biotin) antibody
Blocking Peptide For anti-FZR1 (ARP51279_P050-Biotin) antibody is Catalog # AAP51279 (Previous Catalog # AAPS22306)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1
Uniprot ID Q9UM11
Protein Name Fizzy-related protein homolog
Sample Type Confirmation

FZR1 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Protein Accession # NP_057347
Purification Affinity Purified
Nucleotide Accession # NM_016263
Gene Symbol FZR1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%
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