Product Number |
ARP51279_P050-Biotin |
Product Page |
www.avivasysbio.com/fzr1-antibody-n-terminal-region-biotin-arp51279-p050-biotin.html |
Name |
FZR1 Antibody - N-terminal region : Biotin (ARP51279_P050-Biotin) |
Protein Size (# AA) |
493 amino acids |
Molecular Weight |
55kDa |
Conjugation |
Biotin |
NCBI Gene Id |
51343 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Fizzy/cell division cycle 20 related 1 (Drosophila) |
Alias Symbols |
FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C |
Peptide Sequence |
Synthetic peptide located within the following region: SSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDN |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
Description of Target |
FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
Protein Interactions |
ZC3HC1; CDC25A; CCNB1; UBE2S; UBE2C; PTTG1; UBE2D2; TP53; CDR2; UBE2K; ANAPC4; PDS1; STAU1; CDK2; CDC27; RACGAP1; FOXM1; HECW2; PHF8; BTRC; CCNA1; UBC; SOX2; SKP2; PLK1; CUL1; CUEDC2; CDC20; kif22; SIRT2; CLSPN; ANAPC11; CDC14B; VHL; PTEN; EYA1; DAXX; BUB |
Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
Datasheets/Manuals |
Printable datasheet for anti-FZR1 (ARP51279_P050-Biotin) antibody |
Blocking Peptide |
For anti-FZR1 (ARP51279_P050-Biotin) antibody is Catalog # AAP51279 (Previous Catalog # AAPS22306) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1 |
Uniprot ID |
Q9UM11 |
Protein Name |
Fizzy-related protein homolog |
Sample Type Confirmation |
FZR1 is strongly supported by BioGPS gene expression data to be expressed in 721_B |
Protein Accession # |
NP_057347 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_016263 |
Gene Symbol |
FZR1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100% |
Image 1 | |