| Product Number |
ARP51267_P050 |
| Product Page |
www.avivasysbio.com/park7-antibody-c-terminal-region-arp51267-p050.html |
| Name |
PARK7 Antibody - C-terminal region (ARP51267_P050) |
| Protein Size (# AA) |
189 amino acids |
| Molecular Weight |
20kDa |
| NCBI Gene Id |
11315 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Parkinson protein 7 |
| Alias Symbols |
DJ1, DJ-1, GATD2, HEL-S-67p |
| Peptide Sequence |
Synthetic peptide located within the following region: TYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Mellick,G.D., (er) Parkinsonism Relat. Disord. (2008) In press |
| Description of Target |
PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7.The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. |
| Protein Interactions |
GOPC; VHL; UBC; PARK7; NPM1; BBS1; SNCA; Bax; HIPK1; TDP2; PRDX5; PPARGC1A; FADD; PRDX2; TALDO1; SREBF2; SFPQ; PTEN; NONO; MAP3K5; HSPA4; CASP8; BAG1; ATP5J; AR; PINK1; TP53; SLC18A2; PARK2; NDUFS3; NDUFA4; ND1; MAP1B; CSN1S1; SUMO1; UBE2I; DAXX; UBA2; BC |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for ARP51267_P050 |
| Blocking Peptide |
Catalog # AAP51267 (Previous Catalog # AAPP28415) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human PARK7 |
| Uniprot ID |
Q99497 |
| Protein Name |
Protein DJ-1 |
| Sample Type Confirmation |
PARK7 is supported by BioGPS gene expression data to be expressed in SHSY5Y |
| Protein Accession # |
NP_009193 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_007262 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
PARK7 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 79%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100% |
| Image 1 | Mouse brain
 | Sample Type: Mouse Brain Slices
Red: primary
Blue: DAPI
Primary
Dilution: 1:400
Secondary Antibody: Anti-Rabbit IgG Alexa 594
Secondary
Dilution: 1:400
Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt
University of Seville |
|
| Image 2 | Human SH-SY5Y
 | PARK7 antibody - C-terminal region (ARP51267_P050) validated by WB using SH-SY5Y cell line at 1: 500.PARK7 is supported by BioGPS gene expression data to be expressed in SHSY5Y |
|
| Image 3 | Human HepG2
 | WB Suggested Anti-PARK7 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate |
|
