Product Number |
ARP50507_P050 |
Product Page |
www.avivasysbio.com/atxn3-antibody-n-terminal-region-arp50507-p050.html |
Name |
ATXN3 Antibody - N-terminal region (ARP50507_P050) |
Protein Size (# AA) |
361 amino acids |
Molecular Weight |
41kDa |
NCBI Gene Id |
4287 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Ataxin 3 |
Description |
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Alias Symbols |
AT3, JOS, MJD, ATX3, MJD1, SCA3 |
Peptide Sequence |
Synthetic peptide located within the following region: SIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNAL |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Protein Interactions |
UBC; NEDD8; ATXN3; TRIM63; SQSTM1; VCP; ITCH; PARK2; MGRN1; TUBB; HDAC6; TUBA1A; ELC1; ELA1; SYVN1; BAG3; BCL2L1; STUB1; SUMO1; APP; RFFL; TRIM55; SPRTN; PJA1; TRIM54; USP21; UBE2L3; ARHGDIA; ASIC1; RAD23B; RAD23A; ARHGAP19; C16orf70; TEX11; PICK1; GSK3B; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-ATXN3 (ARP50507_P050) antibody |
Blocking Peptide |
For anti-ATXN3 (ARP50507_P050) antibody is Catalog # AAP50507 (Previous Catalog # AAPP44281) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human ATXN3 |
Uniprot ID |
P54252 |
Protein Name |
Ataxin-3 |
Publications |
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathol. 140, 737-764 (2020) 32642868 |
Protein Accession # |
NP_004984 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_004993 |
Tested Species Reactivity |
Human |
Gene Symbol |
ATXN3 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 92% |
Image 1 | Human 293T
| WB Suggested Anti-ATXN3 Antibody Titration: 0.2-1 ug/ml Positive Control: 293T cell lysate |
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Image 2 | Human
| Lanes: Lane 1: 2ug hATX3 (isoform2); Josephin domain(1-182) Lane 2: 2ug hATX3 (isoform2); C-terminal truncated Atx3 (1-264) Lane 3: 2ug hATX3 (isoform2) Lane 4: 2ug other protein Primary Antibody Dilution: 1:10,000 Secondary Antibody: Anti-rabbit HRP Secondary Antibody Dilution: 1:20,000 Gene Name: ATXN3 Submitted by: Dr. Maria Macedo, Instituto de Biologia Molecular e Celular
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