ATXN3 Antibody - N-terminal region (ARP50507_P050)

Data Sheet
 
Product Number ARP50507_P050
Product Page www.avivasysbio.com/atxn3-antibody-n-terminal-region-arp50507-p050.html
Name ATXN3 Antibody - N-terminal region (ARP50507_P050)
Protein Size (# AA) 361 amino acids
Molecular Weight 41kDa
NCBI Gene Id 4287
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Ataxin 3
Description
Alias Symbols AT3, JOS, MJD, ATX3, MJD1, SCA3
Peptide Sequence Synthetic peptide located within the following region: SIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNAL
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Protein Interactions UBC; NEDD8; ATXN3; TRIM63; SQSTM1; VCP; ITCH; PARK2; MGRN1; TUBB; HDAC6; TUBA1A; ELC1; ELA1; SYVN1; BAG3; BCL2L1; STUB1; SUMO1; APP; RFFL; TRIM55; SPRTN; PJA1; TRIM54; USP21; UBE2L3; ARHGDIA; ASIC1; RAD23B; RAD23A; ARHGAP19; C16orf70; TEX11; PICK1; GSK3B;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-ATXN3 (ARP50507_P050) antibody
Blocking Peptide For anti-ATXN3 (ARP50507_P050) antibody is Catalog # AAP50507 (Previous Catalog # AAPP44281)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ATXN3
Uniprot ID P54252
Protein Name Ataxin-3
Publications

Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathol. 140, 737-764 (2020) 32642868

Protein Accession # NP_004984
Purification Affinity Purified
Nucleotide Accession # NM_004993
Tested Species Reactivity Human
Gene Symbol ATXN3
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 92%
Image 1
Human 293T
WB Suggested Anti-ATXN3 Antibody Titration: 0.2-1 ug/ml
Positive Control: 293T cell lysate
Image 2
Human
Lanes:
Lane 1: 2ug hATX3 (isoform2); Josephin domain(1-182)
Lane 2: 2ug hATX3 (isoform2); C-terminal truncated Atx3 (1-264)
Lane 3: 2ug hATX3 (isoform2)
Lane 4: 2ug other protein
Primary Antibody Dilution:
1:10,000
Secondary Antibody:
Anti-rabbit HRP
Secondary Antibody Dilution:
1:20,000
Gene Name:
ATXN3
Submitted by:
Dr. Maria Macedo, Instituto de Biologia Molecular e Celular
 

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