Product Number |
ARP48940_T100 |
Product Page |
www.avivasysbio.com/setd7-antibody-c-terminal-region-arp48940-t100.html |
Name |
SETD7 Antibody - C-terminal region (ARP48940_T100) |
Protein Size (# AA) |
366 amino acids |
Molecular Weight |
41kDa |
NCBI Gene Id |
80854 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
SET domain containing (lysine methyltransferase) 7 |
Alias Symbols |
KMT7, SET7, SET9, SET7/9 |
Peptide Sequence |
Synthetic peptide located within the following region: PRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Subramanian,K., (2008) Mol. Cell 30 (3), 336-347 |
Description of Target |
SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. It has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. |
Protein Interactions |
KLF4; HIST3H3; SOX2; PRKAR1A; A1BG; TP53; NR2F2; STEAP3; SERTAD1; DPY30; MED1; MYOD1; E2F1; HIST1H3A; SMARCA4; H3F3A; STAT3; RELA; AR; UBC; DNMT1; PPP1R12A; SIRT1; TBP; TAF10; TAF7; TAF6; HIST1H4A; ESR1; HIST2H3C; HCFC1; L3MBTL1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-SETD7 (ARP48940_T100) antibody |
Blocking Peptide |
For anti-SETD7 (ARP48940_T100) antibody is Catalog # AAP48940 (Previous Catalog # AAPP28987) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human SETD7 |
Uniprot ID |
Q8WTS6 |
Protein Name |
Histone-lysine N-methyltransferase SETD7 |
Protein Accession # |
NP_085151 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_030648 |
Tested Species Reactivity |
Human |
Gene Symbol |
SETD7 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86% |
Image 1 | Human Pancreas
| WB Suggested Anti-SETD7 Antibody Titration: 5.0ug/ml Positive Control: Human Pancreas |
|
|