SETD7 Antibody - C-terminal region (ARP48940_T100)

Data Sheet
 
Product Number ARP48940_T100
Product Page www.avivasysbio.com/setd7-antibody-c-terminal-region-arp48940-t100.html
Name SETD7 Antibody - C-terminal region (ARP48940_T100)
Protein Size (# AA) 366 amino acids
Molecular Weight 41kDa
NCBI Gene Id 80854
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name SET domain containing (lysine methyltransferase) 7
Alias Symbols KMT7, SET7, SET9, SET7/9
Peptide Sequence Synthetic peptide located within the following region: PRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAF
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Subramanian,K., (2008) Mol. Cell 30 (3), 336-347
Description of Target SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. It has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.
Protein Interactions KLF4; HIST3H3; SOX2; PRKAR1A; A1BG; TP53; NR2F2; STEAP3; SERTAD1; DPY30; MED1; MYOD1; E2F1; HIST1H3A; SMARCA4; H3F3A; STAT3; RELA; AR; UBC; DNMT1; PPP1R12A; SIRT1; TBP; TAF10; TAF7; TAF6; HIST1H4A; ESR1; HIST2H3C; HCFC1; L3MBTL1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-SETD7 (ARP48940_T100) antibody
Blocking Peptide For anti-SETD7 (ARP48940_T100) antibody is Catalog # AAP48940 (Previous Catalog # AAPP28987)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human SETD7
Uniprot ID Q8WTS6
Protein Name Histone-lysine N-methyltransferase SETD7
Protein Accession # NP_085151
Purification Protein A purified
Nucleotide Accession # NM_030648
Tested Species Reactivity Human
Gene Symbol SETD7
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Image 1
Human Pancreas
WB Suggested Anti-SETD7 Antibody Titration: 5.0ug/ml
Positive Control: Human Pancreas
 

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