Product Number |
ARP48286_T100 |
Product Page |
www.avivasysbio.com/mdh2-antibody-c-terminal-region-arp48286-t100.html |
Name |
MDH2 Antibody - C-terminal region (ARP48286_T100) |
Protein Size (# AA) |
338 amino acids |
Molecular Weight |
33kDa |
NCBI Gene Id |
4191 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
1.0 mg/ml |
Gene Full Name |
Malate dehydrogenase 2, NAD (mitochondrial) |
Description |
|
Alias Symbols |
MDH, MOR1, DEE51, M-MDH, EIEE51, MGC:3559 |
Peptide Sequence |
Synthetic peptide located within the following region: TYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVK |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Rzem,R., (2007) J. Inherit. Metab. Dis. 30 (5), 681-689 |
Description of Target |
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH2 is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
Protein Interactions |
FUS; HUWE1; GRSF1; UBC; MDM2; PARK2; UBD; METTL21B; VCAM1; ITGA4; FN1; ATF2; LDHAL6A; MRPS28; IDH1; CLNS1A; SERPINH1; ATP5B; ATP5A1; CRYAB; COPS5; CDK2; PSMA3; PCNA; HDAC5; Mapk13; PSMD4; PC; WARS; NDUFS1; MDH2; GOT2; FH; CS; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-MDH2 (ARP48286_T100) antibody |
Blocking Peptide |
For anti-MDH2 (ARP48286_T100) antibody is Catalog # AAP48286 (Previous Catalog # AAPY01655) |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human MDH2 |
Uniprot ID |
P40926 |
Protein Name |
Malate dehydrogenase, mitochondrial |
Publications |
Freund, D. M., Prenni, J. E. & Curthoys, N. P. Response of the mitochondrial proteome of rat renal proximal convoluted tubules to chronic metabolic acidosis. Am. J. Physiol. Renal Physiol. 304, F145-55 (2013). 23136003
Povlsen, J. A. et al. Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation. PLoS One 8, e64093 (2013). 23704975 |
Protein Accession # |
NP_005909 |
Purification |
Protein A purified |
Nucleotide Accession # |
NM_005918 |
Tested Species Reactivity |
Human, Rat |
Gene Symbol |
MDH2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92% |
Image 1 | Human HepG2
| WB Suggested Anti-MDH2 Antibody Titration: 2.5ug/ml Positive Control: HepG2 cell lysate |
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Image 2 | Rat kidney
| MDH2 antibody - C-terminal region (ARP48286_T100) validated by WB using Proximal kidney tubules purfied from cortex at 1:1000. |
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