MDH2 Antibody - C-terminal region (ARP48286_T100)

Data Sheet
 
Product Number ARP48286_T100
Product Page www.avivasysbio.com/mdh2-antibody-c-terminal-region-arp48286-t100.html
Name MDH2 Antibody - C-terminal region (ARP48286_T100)
Protein Size (# AA) 338 amino acids
Molecular Weight 33kDa
NCBI Gene Id 4191
Host Rabbit
Clonality Polyclonal
Concentration 1.0 mg/ml
Gene Full Name Malate dehydrogenase 2, NAD (mitochondrial)
Description
Alias Symbols MDH, MOR1, DEE51, M-MDH, EIEE51, MGC:3559
Peptide Sequence Synthetic peptide located within the following region: TYFSTPLLLGKKGIEKNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Rzem,R., (2007) J. Inherit. Metab. Dis. 30 (5), 681-689
Description of Target Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. MDH2 is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interactions FUS; HUWE1; GRSF1; UBC; MDM2; PARK2; UBD; METTL21B; VCAM1; ITGA4; FN1; ATF2; LDHAL6A; MRPS28; IDH1; CLNS1A; SERPINH1; ATP5B; ATP5A1; CRYAB; COPS5; CDK2; PSMA3; PCNA; HDAC5; Mapk13; PSMD4; PC; WARS; NDUFS1; MDH2; GOT2; FH; CS;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-MDH2 (ARP48286_T100) antibody
Blocking Peptide For anti-MDH2 (ARP48286_T100) antibody is Catalog # AAP48286 (Previous Catalog # AAPY01655)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human MDH2
Uniprot ID P40926
Protein Name Malate dehydrogenase, mitochondrial
Publications

Freund, D. M., Prenni, J. E. & Curthoys, N. P. Response of the mitochondrial proteome of rat renal proximal convoluted tubules to chronic metabolic acidosis. Am. J. Physiol. Renal Physiol. 304, F145-55 (2013). 23136003

Povlsen, J. A. et al. Protection against myocardial ischemia-reperfusion injury at onset of type 2 diabetes in Zucker diabetic fatty rats is associated with altered glucose oxidation. PLoS One 8, e64093 (2013). 23704975

Protein Accession # NP_005909
Purification Protein A purified
Nucleotide Accession # NM_005918
Tested Species Reactivity Human, Rat
Gene Symbol MDH2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
Image 1
Human HepG2
WB Suggested Anti-MDH2 Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate
Image 2
Rat kidney
MDH2 antibody - C-terminal region (ARP48286_T100) validated by WB using Proximal kidney tubules purfied from cortex at 1:1000.
 

AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.

AVIVA SYSTEMS BIOLOGY
10211 Pacific Mesa Blvd, Ste 401, San Diego, CA 92121 USA | Tel: (858)552-6979 | info@avivasysbio.com