CLN6 Antibody - C-terminal region (ARP47372_P050)

Data Sheet
Product Number ARP47372_P050
Product Page
Name CLN6 Antibody - C-terminal region (ARP47372_P050)
Protein Size (# AA) 311 amino acids
Molecular Weight 36kDa
NCBI Gene Id 54982
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Ceroid-lipofuscinosis, neuronal 6, late infantile, variant
Alias Symbols nclf, CLN4A, HsT18960
Peptide Sequence Synthetic peptide located within the following region: RLFLDSNGLFLFSSFALTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWA
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Heine,C., (2007) Mol. Membr. Biol. 24 (1), 74-87
Description of Target CLN6 is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely CLN6 involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
Protein Interactions RNF2; BMI1; ILK; env; DERL1; VCP; UBC;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CLN6 (ARP47372_P050) antibody
Blocking Peptide For anti-CLN6 (ARP47372_P050) antibody is Catalog # AAP47372 (Previous Catalog # AAPP28240)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human CLN6
Uniprot ID Q9NWW5
Protein Name Ceroid-lipofuscinosis neuronal protein 6
Sample Type Confirmation

CLN6 is supported by BioGPS gene expression data to be expressed in HEK293T

Protein Accession # NP_060352
Purification Affinity Purified
Nucleotide Accession # NM_017882
Tested Species Reactivity Human
Gene Symbol CLN6
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep, Zebrafish
Application IHC, WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86%
Image 1
Human 293T
WB Suggested Anti-CLN6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: 293T cell lysateCLN6 is supported by BioGPS gene expression data to be expressed in HEK293T
Image 2
Human Pineal Tissue
Rabbit Anti-CLN6 Antibody
Catalog Number: ARP47372_P050
Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue
Observed Staining: Cytoplasmic in cell bodies of pinealocytes
Primary Antibody Concentration: 1:100
Other Working Concentrations: 1/600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Image 3
MCF7, Human stomach
Host: Rabbit
Target: CLN6
Positive control (+): MCF7 (N10)
Negative control (-): Human stomach (ST)
Antibody concentration: 1ug/ml

AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins.

6370 Nancy Ridge Dr., Suite 104, San Diego, CA 92121 USA | Tel: (858)552-6979 |