Product Number |
ARP47180_P050 |
Product Page |
www.avivasysbio.com/coq2-antibody-middle-region-arp47180-p050.html |
Name |
COQ2 Antibody - middle region (ARP47180_P050) |
Protein Size (# AA) |
384 amino acids |
Molecular Weight |
42kDa |
NCBI Gene Id |
27235 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Coenzyme Q2 homolog, prenyltransferase (yeast) |
Alias Symbols |
MSA1, CL640, COQ10D1, PHB:PPT |
Peptide Sequence |
Synthetic peptide located within the following region: FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAML |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Brown,M.A., (2007) J. Am. Soc. Nephrol. 18 (10), 2773-2780 |
Description of Target |
COQ2 catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. COQ2 mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004 [PubMed 15153069]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-90 BC020728.1 1-90 91-96 BG699931.1 80-85 97-789 BC020728.1 97-789 790-792 BQ363759.1 169-171 793-1535 BC020728.1 793-1535 1536-1554 BC008804.2 1496-1514 |
Protein Interactions |
UBC; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-COQ2 (ARP47180_P050) antibody |
Blocking Peptide |
For anti-COQ2 (ARP47180_P050) antibody is Catalog # AAP47180 (Previous Catalog # AAPP27952) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human COQ2 |
Uniprot ID |
Q96H96 |
Protein Name |
4-hydroxybenzoate polyprenyltransferase, mitochondrial |
Publications |
New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Mamm. Genome. 26, 619-29 (2015). 26296322 |
Sample Type Confirmation |
COQ2 is supported by BioGPS gene expression data to be expressed in DU145 |
Protein Accession # |
NP_056512 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_015697 |
Tested Species Reactivity |
Human |
Gene Symbol |
COQ2 |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Goat, Horse, Pig, Rabbit, Yeast, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 93%; Goat: 79%; Horse: 79%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 93%; Rat: 86%; Yeast: 91%; Zebrafish: 86% |
Image 1 | MCF7, HepG2
| Host: Rabbit Target: COQ2 Positive control (+): MCF7 (N10) Negative control (-): HepG2 (HG) Antibody concentration: 1ug/ml |
|
Image 2 | Human MCF7
| Host: Rabbit Target Name: COQ2 Sample Tissue: Human MCF7 Antibody Dilution: 1.0ug/ml |
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