Product Number |
ARP47054_P050-HRP |
Product Page |
www.avivasysbio.com/edem1-antibody-n-terminal-region-hrp-arp47054-p050-hrp.html |
Name |
EDEM1 Antibody - N-terminal region : HRP (ARP47054_P050-HRP) |
Protein Size (# AA) |
657 amino acids |
Molecular Weight |
74kDa |
Conjugation |
HRP: Horseradish Peroxidase |
NCBI Gene Id |
9695 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
ER degradation enhancer, mannosidase alpha-like 1 |
Alias Symbols |
EDEM |
Peptide Sequence |
Synthetic peptide located within the following region: MAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAI |
Product Format |
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
Reference |
Zuber,C., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (11), 4407-4412 |
Description of Target |
EDEM1 belongs to the glycosyl hydrolase 47 family. It extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. |
Protein Interactions |
HLA-B; SQSTM1; UBC; MMS19; SSR1; ASGR1; DERL1; DNAJC10; DERL2; SEC61B; SEL1L; RHO; CANX; RCOM_2159910; ASGR2; ELAVL1; BZW1; |
Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
Datasheets/Manuals |
Printable datasheet for anti-EDEM1 (ARP47054_P050-HRP) antibody |
Blocking Peptide |
For anti-EDEM1 (ARP47054_P050-HRP) antibody is Catalog # AAP47054 (Previous Catalog # AAPP27852) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human EDEM1 |
Uniprot ID |
Q92611 |
Protein Name |
ER degradation-enhancing alpha-mannosidase-like 1 |
Sample Type Confirmation |
EDEM1 is supported by BioGPS gene expression data to be expressed in 721_B |
Protein Accession # |
NP_055489 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_014674 |
Gene Symbol |
EDEM1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Yeast |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82% |
Image 1 | |