| Product Number |
ARP47054_P050 |
| Product Page |
www.avivasysbio.com/edem1-antibody-n-terminal-region-arp47054-p050.html |
| Name |
EDEM1 Antibody - N-terminal region (ARP47054_P050) |
| Protein Size (# AA) |
657 amino acids |
| Molecular Weight |
74kDa |
| NCBI Gene Id |
9695 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
ER degradation enhancer, mannosidase alpha-like 1 |
| Description |
|
| Alias Symbols |
EDEM |
| Peptide Sequence |
Synthetic peptide located within the following region: MAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAI |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Zuber,C., (2007) Proc. Natl. Acad. Sci. U.S.A. 104 (11), 4407-4412 |
| Description of Target |
EDEM1 belongs to the glycosyl hydrolase 47 family. It extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. |
| Protein Interactions |
HLA-B; SQSTM1; UBC; MMS19; SSR1; ASGR1; DERL1; DNAJC10; DERL2; SEC61B; SEL1L; RHO; CANX; RCOM_2159910; ASGR2; ELAVL1; BZW1; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-EDEM1 (ARP47054_P050) antibody |
| Blocking Peptide |
For anti-EDEM1 (ARP47054_P050) antibody is Catalog # AAP47054 (Previous Catalog # AAPP27852) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human EDEM1 |
| Uniprot ID |
Q92611 |
| Protein Name |
ER degradation-enhancing alpha-mannosidase-like 1 |
| Sample Type Confirmation |
EDEM1 is supported by BioGPS gene expression data to be expressed in 721_B |
| Protein Accession # |
NP_055489 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_014674 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
EDEM1 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Yeast |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 93%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82% |
| Image 1 | Human 721_B
 | WB Suggested Anti-EDEM1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysateEDEM1 is supported by BioGPS gene expression data to be expressed in 721_B |
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