LMAN1 Antibody - middle region (ARP46614_T100)

• Product Number: ARP46614_T100
• Name: LMAN1 Antibody - middle region (ARP46614_T100)
• Protein Size (# AA): 510 amino acids
• Molecular Weight: 54kDa
• NCBI Gene Id: 3998
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Lectin, mannose-binding, 1
• Alias Symbols: MR60, gp58, F5F8D, FMFD1, MCFD1, ERGIC53, ERGIC-53
• Peptide Sequence: Synthetic peptide located within the following region: DKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNR
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Neve,E.P., (2005) J. Mol. Biol. 354 (3), 556-568
• Description of Target: LMAN1 is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in its gene are associated with a coagulation defect. Using positional cloning, its gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
• Protein Interactions: UBC; NEDD8; YIPF3; env; PIGS; TMED2; YBX1; HSP90AA1; HNRNPU; APP; UBXN6; RAB3GAP2; RAB3GAP1; COPE; TUBB4B; TUBB3; COPB2; VCP; DNAJC7; P4HB; HSPA8; HSPA1A; COPB1; COPA; BCAP29; BCAP31; HLA-A; CANX; ELAVL1; MCFD2; F8;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-LMAN1 (ARP46614_T100) antibody is Catalog # AAP46614 (Previous Catalog # AAPS19802)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LMAN1
• Uniprot ID: P49257
• Protein Name: Protein ERGIC-53
• Protein Accession #: NP_005561
• Purification: Protein A purified
• Nucleotide Accession #: NM_005570
• Tested Species Reactivity: Human
• Gene Symbol: LMAN1
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea Pig: 90%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
• Image 1: Human HepG2
  
  WB Suggested Anti-LMAN1 Antibody Titration: 1.25ug/ml
  Positive Control: HepG2 cell lysate