| Product Number |
ARP46583_P050-FITC |
| Product Page |
www.avivasysbio.com/dcc-antibody-middle-region-fitc-arp46583-p050-fitc.html |
| Name |
DCC Antibody - middle region : FITC (ARP46583_P050-FITC) |
| Protein Size (# AA) |
1447 amino acids |
| Molecular Weight |
158kDa |
| Conjugation |
FITC: Fluorescein Isothiocyanate |
| NCBI Gene Id |
1630 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Deleted in colorectal carcinoma |
| Alias Symbols |
CRC18, CRCR1, MRMV1, HGPPS2, IGDCC1, NTN1R1 |
| Peptide Sequence |
Synthetic peptide located within the following region: PIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQ |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
| Description of Target |
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. |
| Protein Interactions |
UBC; ALB; BARD1; sina; UBI4; SIAH2; EIF4E3; EIF2A; EIF5A2; NTN1; RPL23; EIF2S2; EIF2B2; EIF2B4; EZR; RPS24; RPS13; RPS10; RPS6; RPS4X; RPL38; RPL28; RPL13; RPL5; PTK2; MAPK1; RPL10A; EIF3E; EIF4E; EIF2S3; EIF2B1; EIF1AX; ADORA2B; APPL1; CASP9; SIAH1; MAPK |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-DCC (ARP46583_P050-FITC) antibody |
| Blocking Peptide |
For anti-DCC (ARP46583_P050-FITC) antibody is Catalog # AAP46583 (Previous Catalog # AAPS19506) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human DCC |
| Uniprot ID |
P43146 |
| Protein Name |
Netrin receptor DCC |
| Protein Accession # |
NP_005206 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_005215 |
| Gene Symbol |
DCC |
| Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | |
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