CENPM Antibody - middle region (ARP46323_P050)

• Product Number: ARP46323_P050
• Name: CENPM Antibody - middle region (ARP46323_P050)
• Protein Size (# AA): 180 amino acids
• Molecular Weight: 20kDa
• NCBI Gene Id: 79019
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Centromere protein M
• Alias Symbols: PANE1, CENP-M, C22orf18
• Peptide Sequence: Synthetic peptide located within the following region: CDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Izuta,H., (2006) Genes Cells 11 (6), 673-684
• Description of Target: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA replaces histone H3. CENPM is an additional factor required for centromere assembly.The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM].
• Protein Interactions: CENPP; CENPL; CENPT; CENPU; CENPO; CENPK; CENPN; CENPQ; CENPI; CENPC; CENPA; UBC;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-CENPM (ARP46323_P050) antibody is Catalog # AAP46323 (Previous Catalog # AAPS18008)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CENPM
• Uniprot ID: Q9NSP4
• Protein Name: Centromere protein M
• Protein Accession #: NP_076958
• Purification: Affinity Purified
• Nucleotide Accession #: NM_024053
• Tested Species Reactivity: Human
• Gene Symbol: CENPM
• Predicted Species Reactivity: Human, Cow, Dog, Horse, Pig, Rabbit
• Application: IF, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 79%; Dog: 79%; Horse: 93%; Human: 100%; Pig: 93%; Rabbit: 93%
• Image 1: DNA/ACA
  
  Sample Type : DNA/ACA
  
• Image 2: Human HepG2
  
  WB Suggested Anti-CENPM Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:312500
  Positive Control: HepG2 cell lysate