| Product Number |
ARP46104_P050 |
| Product Page |
www.avivasysbio.com/cad-antibody-c-terminal-region-arp46104-p050.html |
| Name |
CAD Antibody - C-terminal region (ARP46104_P050) |
| Protein Size (# AA) |
2225 amino acids |
| Molecular Weight |
243kDa |
| NCBI Gene Id |
790 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| Alias Symbols |
CDG1Z, DEE50, GATD4, EIEE50 |
| Peptide Sequence |
Synthetic peptide located within the following region: ADVVVLRHPQPGAVELAAKHCRRPVINAGDGVGEHPTQALLDIFTIREEL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Olsen,J.V., (2006) Cell 127 (3), 635-648 |
| Description of Target |
CAD is a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
UBC; TUBG1; TP53; SUMO2; SPRTN; STAU1; LGR4; SUMO1; NEDD8; WWOX; NEDD4; FBXO6; HDAC6; ILK; CDK2; HDAC11; HTRA2; TP63; NOS2; ITGA4; RUVBL1; XPO1; VARS; TUBB2A; TUBA4A; SMARCC2; SMARCA4; RPS3; PSMD1; PSMC2; RUVBL2; TUBB4B; SHC1; SMAD2; GRB2; CBL; CUL3; FBXO |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CAD (ARP46104_P050) antibody |
| Blocking Peptide |
For anti-CAD (ARP46104_P050) antibody is Catalog # AAP46104 (Previous Catalog # AAPP26966) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human CAD |
| Uniprot ID |
P27708 |
| Protein Name |
CAD protein |
| Protein Accession # |
NP_004332 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_004341 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CAD |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 100% |
| Image 1 | Human Lung
 | WB Suggested Anti-CAD Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Lung |
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