| Product Number |
ARP45719_T100 |
| Product Page |
www.avivasysbio.com/sbds-antibody-n-terminal-region-arp45719-t100.html |
| Name |
SBDS Antibody - N-terminal region (ARP45719_T100) |
| Protein Size (# AA) |
250 amino acids |
| Molecular Weight |
28kDa |
| NCBI Gene Id |
51119 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Shwachman-Bodian-Diamond syndrome |
| Alias Symbols |
SDS, SDO1, SWDS, CGI-97 |
| Peptide Sequence |
Synthetic peptide located within the following region: LQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKER |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Austin,K.M., (2005) Blood 106 (4), 1253-1258 |
| Description of Target |
SBDS is a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The protein may function in RNA metabolism. Mutations within its gene are associated with Shwachman-Bodian-Diamond syndrome.This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. |
| Protein Interactions |
SUMO2; TYMS; PNP; IDH1; GOT1; UBC; CHAMP1; MPLKIP; MRPL53; SARNP; SLIRP; SRPRB; ACOT13; SRRM2; TIMM44; TOMM40; UBE4B; SCO2; SNX3; STX7; SF1; VDAC3; TIAL1; SPR; RBMS1; NDUFA7; NDUFA2; IDH3G; STOM; ACAA1; ACD; TERF2IP; POT1; TERF1; CLN3; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-SBDS (ARP45719_T100) antibody |
| Blocking Peptide |
For anti-SBDS (ARP45719_T100) antibody is Catalog # AAP45719 (Previous Catalog # AAPP11852) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human SBDS |
| Uniprot ID |
Q9Y3A5 |
| Protein Name |
Ribosome maturation protein SBDS |
| Publications |
Sezgin, G. et al. Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS. Pediatr. Blood Cancer 60, 281-6 (2013). 22997148 |
| Protein Accession # |
NP_057122 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_016038 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
SBDS |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 85% |
| Image 1 | Human Jurkat
 | WB Suggested Anti-SBDS Antibody Titration: 2.5ug/ml
Positive Control: Jurkat cell lysate |
|
| Image 2 | Human kidney
 | Human kidney |
|
