NR1H4 Antibody - middle region (ARP45626_P050)

Data Sheet
 
Product Number ARP45626_P050
Product Page www.avivasysbio.com/nr1h4-antibody-middle-region-arp45626-p050.html
Name NR1H4 Antibody - middle region (ARP45626_P050)
Protein Size (# AA) 472 amino acids
Molecular Weight 56 kDa
NCBI Gene Id 9971
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Nuclear receptor subfamily 1, group H, member 4
Alias Symbols BAR, FXR, HRR1, HRR-1, PFIC5, RIP14
Peptide Sequence Synthetic peptide located within the following region: SAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSI
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kaeding,J., (2008) Biochem. J. 410 (2), 245-253
Description of Target NR1H4 is the receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. NR1H4 represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two d
Protein Interactions SMARCD3; HDAC6; SUMO1; NCOR2; ESR1; RRM2; GPS2; RXRG; GAPDH; RXRA; EP300; SIRT1; SRC; NCOA6; CARM1; HIST1H4A; HIST1H3A; PRMT1; NCOR1; XRCC5; PRKDC; XRCC6; NCOA1; CASP8; SMARCD1;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-NR1H4 (ARP45626_P050) antibody
Blocking Peptide For anti-NR1H4 (ARP45626_P050) antibody is Catalog # AAP45626 (Previous Catalog # AAPP11909)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human NR1H4
Uniprot ID B6ZGS9
Protein Name Farnesoid X receptor EMBL BAH02290.1
Publications

Yamada, T. et al. Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells. Anticancer Res. 30, 1953-60 (2010). 20651339

Protein Accession # NP_005114
Purification Affinity Purified
Nucleotide Accession # NM_005123
Tested Species Reactivity Human
Gene Symbol NR1H4
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93%
Image 1

25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. The protein may be modified by acetylation and phosphorylation.
 

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