Product Number |
ARP45626_P050 |
Product Page |
www.avivasysbio.com/nr1h4-antibody-middle-region-arp45626-p050.html |
Name |
NR1H4 Antibody - middle region (ARP45626_P050) |
Protein Size (# AA) |
472 amino acids |
Molecular Weight |
56 kDa |
NCBI Gene Id |
9971 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Nuclear receptor subfamily 1, group H, member 4 |
Alias Symbols |
BAR, FXR, HRR1, HRR-1, PFIC5, RIP14 |
Peptide Sequence |
Synthetic peptide located within the following region: SAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSI |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Kaeding,J., (2008) Biochem. J. 410 (2), 245-253 |
Description of Target |
NR1H4 is the receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. NR1H4 represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two d |
Protein Interactions |
SMARCD3; HDAC6; SUMO1; NCOR2; ESR1; RRM2; GPS2; RXRG; GAPDH; RXRA; EP300; SIRT1; SRC; NCOA6; CARM1; HIST1H4A; HIST1H3A; PRMT1; NCOR1; XRCC5; PRKDC; XRCC6; NCOA1; CASP8; SMARCD1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-NR1H4 (ARP45626_P050) antibody |
Blocking Peptide |
For anti-NR1H4 (ARP45626_P050) antibody is Catalog # AAP45626 (Previous Catalog # AAPP11909) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human NR1H4 |
Uniprot ID |
B6ZGS9 |
Protein Name |
Farnesoid X receptor EMBL BAH02290.1 |
Publications |
Yamada, T. et al. Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells. Anticancer Res. 30, 1953-60 (2010). 20651339 |
Protein Accession # |
NP_005114 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_005123 |
Tested Species Reactivity |
Human |
Gene Symbol |
NR1H4 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 93%; Rat: 93% |
Image 1 |
| 25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 3 ug/mL of the antibody was used in this experiment. The protein may be modified by acetylation and phosphorylation.
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