| Product Number |
ARP45041_P050 |
| Product Page |
www.avivasysbio.com/acvr2b-antibody-middle-region-arp45041-p050.html |
| Name |
ACVR2B Antibody - middle region (ARP45041_P050) |
| Protein Size (# AA) |
512 amino acids |
| Molecular Weight |
58kDa |
| NCBI Gene Id |
93 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Activin A receptor, type IIB |
| Description |
|
| Alias Symbols |
HTX4, ACTRIIB, ActR-IIB |
| Peptide Sequence |
Synthetic peptide located within the following region: LCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for |
| Protein Interactions |
GDF2; BMP10; INHBA; PEG10; ERBB2IP; HSP90AA1; SMAD7; SMAD6; SMAD2; IGSF1; SYNJ2BP; SNX6; SNX2; TGFBRAP1; GDF11; MSTN; ACVR1B; SNX1; INHBC; GDF5; INHBB; BMP7; BMP2; ENG; BMP6; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-ACVR2B (ARP45041_P050) antibody |
| Blocking Peptide |
For anti-ACVR2B (ARP45041_P050) antibody is Catalog # AAP45041 (Previous Catalog # AAPP12329) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human ACVR2B |
| Uniprot ID |
Q13705 |
| Protein Name |
Activin receptor type-2B |
| Publications |
TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation. J Cell Sci. 132, (2019). 31217285
The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery. Cell Rep. 25, 1841-1855.e5 (2018). 30428352 |
| Protein Accession # |
NP_001097 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001106 |
| Tested Species Reactivity |
Human, Mouse |
| Gene Symbol |
ACVR2B |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86% |
| Image 1 | Human PANC1
 | WB Suggested Anti-ACVR2B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: PANC1 cell lysate |
|
| Image 2 | Human Fetal Liver
 | Host: Rabbit
Target Name: FAM46C
Sample Type: Human Fetal Liver
Antibody Dilution: 1.0ug/ml |
|
| Image 3 | Human Fetal Heart
 | Host: Rabbit
Target Name: GNAS
Sample Type: Human Fetal Heart
Antibody Dilution: 1.0ug/ml |
|
| Image 4 | Human Fetal Muscle
 | Host: Rabbit
Target Name: NOP56
Sample Type: Human Fetal Muscle
Antibody Dilution: 1.0ug/ml |
|
| Image 5 | Mouse Skeletal Muscle
 | Host: Mouse
Target Name: ACVR2B
Sample Tissue: Mouse Skeletal Muscle
Antibody Dilution: 1ug/ml |
|
