DTX2 Antibody - C-terminal region (ARP43285_P050)

Data Sheet
 
Product Number ARP43285_P050
Product Page www.avivasysbio.com/dtx2-antibody-c-terminal-region-arp43285-p050.html
Name DTX2 Antibody - C-terminal region (ARP43285_P050)
Protein Size (# AA) 575 amino acids
Molecular Weight 62kDa
NCBI Gene Id 113878
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Deltex homolog 2 (Drosophila)
Alias Symbols RNF58
Peptide Sequence Synthetic peptide located within the following region: EDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLE
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Protein Interactions KRTAP26-1; RFX6; KLC3; GLYCTK; DTX2; RIMBP3; C1orf94; NCALD; PLEKHF2; TRIM54; EIF4ENIF1; ALKBH4; UBE2D4; HPCAL4; SPG21; SEC22A; SPAG8; STX12; NCS1; FAM168A; RBPMS; SEC23B; ABHD16A; VSNL1; SUMO1; UBE2D3; UBE2D1; UBC; TRIP6; QARS; HDC; GOLGA2; FHL2; ARNT2;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-DTX2 (ARP43285_P050) antibody
Blocking Peptide For anti-DTX2 (ARP43285_P050) antibody is Catalog # AAP43285 (Previous Catalog # AAPP11360)
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human DTX2
Uniprot ID Q6XM87
Protein Name Probable E3 ubiquitin-protein ligase DTX2
Protein Accession # NP_001096066
Purification Affinity Purified
Nucleotide Accession # NM_001102596
Tested Species Reactivity Human
Gene Symbol DTX2
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
Image 1
Human HepG2
WB Suggested Anti-DTX2 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
 

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