RNF31 Antibody - middle region : FITC (ARP43241_P050-FITC)

• Product Number: ARP43241_P050-FITC
• Name: RNF31 Antibody - middle region : FITC (ARP43241_P050-FITC)
• Protein Size (# AA): 1072 amino acids
• Molecular Weight: 120kDa
• Conjugation: FITC: Fluorescein Isothiocyanate
• NCBI Gene Id: 55072
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Ring finger protein 31
• Alias Symbols: HOIP, Paul, ZIBRA
• Peptide Sequence: Synthetic peptide located within the following region: SLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKL
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Reference: Kirisako,T., (2006) EMBO J. 25 (20), 4877-4887
• Description of Target: PWP2 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.
• Protein Interactions: CCDC24; VASN; KRTAP9-2; TSSC4; UBC; SNRPC; PRKCA; AES; PITX1; KIF1A; SHARPIN; RBCK1; RNF31; MALT1; VCP; OTULIN; IRAK1; ESR1; Ikbkg; CCDC14; WRNIP1; AKAP8L; TRAF2; TNF; NDUFA8; BIRC2; NOD2; BIRC3; HCVgp1; SOCS3; SMAD3; NOS3; UBE2D3; UBE2D1; TNFAIP3; GFI1B;
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Blocking Peptide: For anti-RNF31 (ARP43241_P050-FITC) antibody is Catalog # AAP43241 (Previous Catalog # AAPP26473)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RNF31
• Uniprot ID: Q96EP0
• Protein Name: E3 ubiquitin-protein ligase RNF31
• Publications:

  Queisser, M. A. et al. HOIL-1L Functions as the PKC? Ubiquitin Ligase to Promote Lung Tumor Growth. (2014). at WB, Human, Rabbit, Rat, Guinea pig, Bovine, Dog, Mouse, Horse 25118570

  Sieber, S. et al. Sharpin contributes to TNF-alpha dependent NF?B activation and anti-apoptotic signalling in hepatocytes. PLoS One 7, e29993 (2012). WB, IP, Human, Rabbit, Rat, Guinea pig, Bovine, Dog, Mouse, Horse 22253853

  Smit, J. J. et al. The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. EMBO J. 31, 3833-44 (2012). WB, IP, Human, Rabbit, Rat, Guinea pig, Bovine, Dog, Mouse, Horse 22863777

  Blackwell, K. et al. Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed I?B kinase activation. Mol. Cell. Biol. 33, 1901-15 (2013). WB, IP, Human, Rabbit, Rat, Guinea pig, Bovine, Dog, Mouse, Horse 23459942

  Liu, S. et al. MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife 2, e00785 (2013). WB, IP, Human, Rabbit, Rat, Guinea pig, Bovine, Dog, Mouse, Horse 23951545

• Protein Accession #: NP_060469
• Purification: Affinity Purified
• Nucleotide Accession #: NM_017999
• Gene Symbol: RNF31
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 92%; Rabbit: 100%; Rat: 100%
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