RNF6 Antibody - N-terminal region (ARP43064_P050)

• Product Number: ARP43064_P050
• Name: RNF6 Antibody - N-terminal region (ARP43064_P050)
• Protein Size (# AA): 685 amino acids
• Molecular Weight: 78kDa
• NCBI Gene Id: 6049
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Ring finger protein (C3H2C3 type) 6
• Alias Symbols: DKFZp686P0776
• Peptide Sequence: Synthetic peptide located within the following region: LQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRTG
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Tursun,B., (2005) Genes Dev. 19 (19), 2307-2319
• Description of Target: RNF6 contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
• Protein Interactions: UBE2D1; AR; LDB1; UBC; tat; UBE2H;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-RNF6 (ARP43064_P050) antibody is Catalog # AAP43064 (Previous Catalog # AAPP25040)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RNF6
• Uniprot ID: Q9Y252
• Protein Name: E3 ubiquitin-protein ligase RNF6
• Protein Accession #: NP_005968
• Purification: Affinity Purified
• Nucleotide Accession #: NM_005977
• Tested Species Reactivity: Human
• Gene Symbol: RNF6
• Predicted Species Reactivity: Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 85%; Dog: 86%; Guinea Pig: 85%; Horse: 86%; Human: 100%; Pig: 86%; Rabbit: 85%; Rat: 86%
• Image 1: Human Spleen
  
  WB Suggested Anti-RNF6 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:62500
  Positive Control: Human Spleen